Kavli Institute for Systems Neuroscience and Centre for the Biology of Memory, MTFS, Norwegian University of Science and Technology, Trondheim, Norway.
Nat Neurosci. 2010 Aug;13(8):987-94. doi: 10.1038/nn.2602. Epub 2010 Jul 25.
Allocentric space is mapped by a widespread brain circuit of functionally specialized cell types located in interconnected subregions of the hippocampal-parahippocampal cortices. Little is known about the neural architectures required to express this variety of firing patterns. In rats, we found that one of the cell types, the grid cell, was abundant not only in medial entorhinal cortex (MEC), where it was first reported, but also in pre- and parasubiculum. The proportion of grid cells in pre- and parasubiculum was comparable to deep layers of MEC. The symmetry of the grid pattern and its relationship to the theta rhythm were weaker, especially in presubiculum. Pre- and parasubicular grid cells intermingled with head-direction cells and border cells, as in deep MEC layers. The characterization of a common pool of space-responsive cells in architecturally diverse subdivisions of parahippocampal cortex constrains the range of mechanisms that might give rise to their unique functional discharge phenotypes.
非自我中心空间由广泛分布的大脑回路映射而成，这些回路中的功能特化细胞类型位于海马体-旁海马皮质的相互连接的亚区中。目前对于表达这种多样化放电模式所需的神经结构知之甚少。在大鼠中，我们发现其中一种细胞类型，网格细胞，不仅在最初报道的内侧内嗅皮层（MEC）中丰富，而且在前内嗅皮层和副嗅皮层中也很丰富。前内嗅皮层和副嗅皮层中网格细胞的比例与 MEC 的深层相当。网格模式的对称性及其与 theta 节律的关系较弱，尤其是在前内嗅皮层。前内嗅皮层和副内嗅皮层的网格细胞与头方向细胞和边界细胞交织在一起，就像在 MEC 的深层一样。在结构上多样化的旁海马皮质分区中共同存在的空间反应细胞的特征限制了可能导致其独特功能放电表型的机制范围。
