Solstad Trygve, Boccara Charlotte N, Kropff Emilio, Moser May-Britt, Moser Edvard I
Kavli Institute for Systems Neuroscience and Centre for the Biology of Memory, Norwegian University of Science and Technology, 7489 Trondheim, Norway.
Science. 2008 Dec 19;322(5909):1865-8. doi: 10.1126/science.1166466.
We report the existence of an entorhinal cell type that fires when an animal is close to the borders of the proximal environment. The orientation-specific edge-apposing activity of these "border cells" is maintained when the environment is stretched and during testing in enclosures of different size and shape in different rooms. Border cells are relatively sparse, making up less than 10% of the local cell population, but can be found in all layers of the medial entorhinal cortex as well as the adjacent parasubiculum, often intermingled with head-direction cells and grid cells. Border cells may be instrumental in planning trajectories and anchoring grid fields and place fields to a geometric reference frame.
我们报告了一种内嗅细胞类型的存在，当动物靠近近端环境的边界时，这种细胞会放电。当环境被拉伸时，以及在不同房间中不同大小和形状的围栏内进行测试时，这些“边界细胞”的方向特异性边缘对立活动都会保持。边界细胞相对稀少，占局部细胞群体的比例不到10%，但在内侧内嗅皮层的所有层以及相邻的副海马体中都能找到，它们常常与头部方向细胞和网格细胞混合在一起。边界细胞可能有助于规划轨迹，并将网格场和位置场锚定到几何参考框架上。
