Scrafton David K, Taylor James E, Mahon Mary F, Fossey John S, James Tony D
Department of Chemistry, The University of Bath, Claverton Down, Bath, BA2 7AY, UK.
J Org Chem. 2008 Apr 4;73(7):2871-4. doi: 10.1021/jo702584u. Epub 2008 Mar 13.
A carbohydrate sensing "click-fluor" is reported which displays a nontypical binding preference with sample saccharides. That a fluorescent sensor is generated as a result of triazole formation (click reaction), rather than simply bringing the sensor and reporter units together via a triazole linkage, and the potential applicability of the wide range of easily accessible acetylene units means a simple strategy for the development of modular fluorescent sensor arrays for rapid screening of target saccharides will be available.
报道了一种碳水化合物传感“点击荧光”物质，它对样品糖类表现出非典型的结合偏好。由于三唑形成（点击反应）而产生荧光传感器，而非简单地通过三唑连接将传感器和报告单元结合在一起，并且大量易于获得的乙炔单元的潜在适用性意味着将有一个简单的策略来开发用于快速筛选目标糖类的模块化荧光传感器阵列。
