通过聚合酶链反应检测贝尔麻痹患者泪液中的人疱疹病毒6型和水痘-带状疱疹病毒。
Detection of human herpesvirus 6 and varicella-zoster virus in tear fluid of patients with Bell's palsy by PCR.
作者信息
Pitkäranta A, Piiparinen H, Mannonen L, Vesaluoma M, Vaheri A
机构信息
Department of Otorhinolaryngology, University of Helsinki, Helsinki, Finland.
出版信息
J Clin Microbiol. 2000 Jul;38(7):2753-5. doi: 10.1128/JCM.38.7.2753-2755.2000.
Abstract
Human herpesvirus 6 DNA was detected by PCR in the tear fluid of 7 (35%) of 20 patients with Bell's palsy and of 1 (5%) of 20 healthy controls. Varicella-zoster virus was detected by PCR in the tear fluid of 2 of 20 Bell's palsy patients but in none of the tear fluids from 20 healthy controls. These findings suggest an association between human herpesviruses and Bell's palsy.
摘要
通过聚合酶链反应（PCR）在20例贝尔麻痹患者的7例（35%）泪液中检测到人类疱疹病毒6型DNA，在20例健康对照者的1例（5%）泪液中也检测到该病毒。通过PCR在20例贝尔麻痹患者的2例泪液中检测到水痘-带状疱疹病毒，但在20例健康对照者的泪液中均未检测到。这些发现提示人类疱疹病毒与贝尔麻痹之间存在关联。
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本文引用的文献
1
Human herpesvirus-6: neurologic implications of a newly-described viral pathogen.人类疱疹病毒6型：一种新发现的病毒病原体的神经学意义
J Neurovirol. 1998 Oct;4(5):474-85. doi: 10.3109/13550289809113492.
2
Reactivation of herpes simplex virus type 1 in patients with Bell's palsy.贝尔麻痹患者中单纯疱疹病毒1型的再激活
J Med Virol. 1998 Mar;54(3):162-6. doi: 10.1002/(sici)1096-9071(199803)54:3<162::aid-jmv3>3.0.co;2-3.
3
Molecular evidence and clinical significance of herpesvirus coinfection in the central nervous system.中枢神经系统中疱疹病毒合并感染的分子证据及临床意义
J Clin Microbiol. 1997 Nov;35(11):2869-72. doi: 10.1128/jcm.35.11.2869-2872.1997.
4
Detection of herpes simplex virus DNA in cerebrospinal fluid samples using the polymerase chain reaction and microplate hybridization.使用聚合酶链反应和微孔板杂交技术检测脑脊液样本中的单纯疱疹病毒DNA。
J Virol Methods. 1996 May;59(1-2):1-11. doi: 10.1016/0166-0934(95)01991-x.
5
Detection of varicella-zoster virus-specific DNA sequences in cerebrospinal fluid from patients with acute aseptic meningitis and no cutaneous lesions.在无皮肤病变的急性无菌性脑膜炎患者的脑脊液中检测水痘-带状疱疹病毒特异性DNA序列。
J Med Virol. 1994 Aug;43(4):331-5. doi: 10.1002/jmv.1890430403.
6
Bell palsy and herpes simplex virus: identification of viral DNA in endoneurial fluid and muscle.贝尔麻痹与单纯疱疹病毒：神经内膜液和肌肉中病毒DNA的鉴定
Ann Intern Med. 1996 Jan 1;124(1 Pt 1):27-30. doi: 10.7326/0003-4819-124-1_part_1-199601010-00005.
7
An ELISA study on varicella-zoster virus infection in acute peripheral facial palsy.急性周围性面神经麻痹水痘-带状疱疹病毒感染的酶联免疫吸附测定研究
Acta Otolaryngol Suppl. 1988;446:10-6. doi: 10.3109/00016488709121834.
8
Epidermal growth factor is a constant component of normal human tear fluid.
Graefes Arch Clin Exp Ophthalmol. 1989;227(2):184-7. doi: 10.1007/BF02169794.
9
Detection by PCR of HHV-6 and EBV DNA in blood and oropharynx of healthy adults and HIV-seropositives.通过聚合酶链反应（PCR）检测健康成年人及HIV血清阳性者血液和口咽中的人疱疹病毒6型（HHV-6）和EB病毒（EBV）DNA 。
Lancet. 1990 Jun 30;335(8705):1598-9. doi: 10.1016/0140-6736(90)91433-b.
10
Genotyping of herpes simplex viruses by polymerase chain reaction.通过聚合酶链反应对单纯疱疹病毒进行基因分型。
Arch Virol. 1991;119(3-4):275-83. doi: 10.1007/BF01310676.
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