Rucktäschel Robert, Girzalsky Wolfgang, Erdmann Ralf
Abteilung für Systembiochemie, Institut für Physiologische Chemie, Medizinische Fakultät der Ruhr-Universität Bochum, D-44780 Bochum, Germany.
Biochim Biophys Acta. 2011 Mar;1808(3):892-900. doi: 10.1016/j.bbamem.2010.07.020. Epub 2010 Jul 24.
Peroxisomes are a class of structurally and functionally related organelles present in almost all eukaryotic cells. The importance of peroxisomes for human life is highlighted by severe inherited diseases which are caused by defects of peroxins, encoded by PEX genes. To date 32 peroxins are known to be involved in different aspects of peroxisome biogenesis. This review addresses two of these aspects, the translocation of soluble proteins into the peroxisomal matrix and the biogenesis of the peroxisomal membrane. This article is part of a Special Issue entitled Protein translocation across or insertion into membranes.
过氧化物酶体是一类结构和功能相关的细胞器，几乎存在于所有真核细胞中。由PEX基因编码的过氧化物酶体蛋白（peroxin）缺陷所导致的严重遗传性疾病，凸显了过氧化物酶体对人类生命的重要性。迄今为止，已知有32种过氧化物酶体蛋白参与过氧化物酶体生物发生的不同方面。本综述探讨其中两个方面，即可溶性蛋白质向过氧化物酶体基质的转运以及过氧化物酶体膜的生物发生。本文是名为“蛋白质跨膜转运或插入膜”的特刊的一部分。
