Girzalsky Wolfgang, Platta Harald W, Erdmann Ralf
Abteilung für Systembiochemie, Medizinische Fakultät der Ruhr-Universität Bochum, D-44780 Bochum, Germany.
Biol Chem. 2009 Aug;390(8):745-51. doi: 10.1515/BC.2009.104.
The maintenance of peroxisome function depends on the formation of the peroxisomal membrane and the subsequent import of both membrane and matrix proteins. Without exception, peroxisomal matrix proteins are nuclear encoded, synthesized on free ribosomes and subsequently imported post-translationally. In contrast to other translocation systems that transport unfolded polypeptide chains, the peroxisomal import apparatus can facilitate the transport of folded and oligomeric proteins across the peroxisomal membrane. The peroxisomal protein import is mediated by cycling receptors that shuttle between the cytosol and peroxisomal lumen and depends on ATP and ubiquitin. In this brief review, we will summarize our current knowledge on the import of soluble proteins into the peroxisomal matrix.
过氧化物酶体功能的维持依赖于过氧化物酶体膜的形成以及随后膜蛋白和基质蛋白的导入。无一例外，过氧化物酶体基质蛋白由细胞核编码，在游离核糖体上合成，随后进行翻译后导入。与其他转运未折叠多肽链的转运系统不同，过氧化物酶体导入装置能够促进折叠和寡聚蛋白穿过过氧化物酶体膜的转运。过氧化物酶体蛋白的导入由在细胞质和过氧化物酶体腔之间循环穿梭的受体介导，并且依赖于ATP和泛素。在这篇简短的综述中，我们将总结目前关于可溶性蛋白导入过氧化物酶体基质的知识。
