Brugada 综合征的病理生理学机制：去极化与复极化。
The pathophysiological mechanism underlying Brugada syndrome: depolarization versus repolarization.
机构信息
Department of Cardiology, Academic Medical Center Amsterdam, Amsterdam, The Netherlands.
出版信息
J Mol Cell Cardiol. 2010 Oct;49(4):543-53. doi: 10.1016/j.yjmcc.2010.07.012. Epub 2010 Jul 24.
Abstract
This Point/Counterpoint presents a scholarly debate of the mechanisms underlying the electrocardiographic and arrhythmic manifestations of Brugada syndrome (BrS), exploring in detail the available evidence in support of the repolarization vs. depolarization hypothesis.
摘要
本观点对论呈现了一场关于 Brugada 综合征（BrS）心电图和心律失常表现背后机制的学术辩论，详细探讨了支持复极与去极化假说的现有证据。
相似文献
1
The pathophysiological mechanism underlying Brugada syndrome: depolarization versus repolarization.Brugada 综合征的病理生理学机制：去极化与复极化。
J Mol Cell Cardiol. 2010 Oct;49(4):543-53. doi: 10.1016/j.yjmcc.2010.07.012. Epub 2010 Jul 24.
2
Mechanisms Underlying Epicardial Radiofrequency Ablation to Suppress Arrhythmogenesis in Experimental Models of Brugada Syndrome.心外膜射频消融抑制 Brugada 综合征实验模型心律失常发生的机制。
JACC Clin Electrophysiol. 2017 Apr;3(4):353-363. doi: 10.1016/j.jacep.2016.10.011. Epub 2016 Dec 21.
3
Electrocardiographic parameters and fatal arrhythmic events in patients with Brugada syndrome: combination of depolarization and repolarization abnormalities. Brugada 综合征患者的心电图参数与致命性心律失常事件：去极化和复极化异常的联合。
J Am Coll Cardiol. 2014 May 27;63(20):2131-2138. doi: 10.1016/j.jacc.2014.01.072. Epub 2014 Apr 2.
4
Cardiac electrophysiological substrate underlying the ECG phenotype and electrogram abnormalities in Brugada syndrome patients.Brugada综合征患者心电图表型和心内膜电图异常背后的心脏电生理基质。
Circulation. 2015 Jun 2;131(22):1950-9. doi: 10.1161/CIRCULATIONAHA.114.013698. Epub 2015 Mar 25.
5
J-wave syndromes caused by repolarization or depolarization mechanisms a debated issue among experimental and clinical electrophysiologists.由复极化或去极化机制引起的J波综合征是实验和临床电生理学家之间争论的问题。
J Am Coll Cardiol. 2010 Feb 23;55(8):798-800. doi: 10.1016/j.jacc.2009.12.006.
6
Simultaneous Non-Invasive Epicardial and Endocardial Mapping in Patients With Brugada Syndrome: New Insights Into Arrhythmia Mechanisms. Brugada 综合征患者的同步心外膜和心内膜无创标测：心律失常机制的新见解。
J Am Heart Assoc. 2016 Nov 14;5(11):e004095. doi: 10.1161/JAHA.116.004095.
7
Local depolarization abnormalities are the dominant pathophysiologic mechanism for type 1 electrocardiogram in brugada syndrome a study of electrocardiograms, vectorcardiograms, and body surface potential maps during ajmaline provocation.局部去极化异常是 1 型 Brugada 综合征心电图的主要病理生理机制：一项关于心电图、向量心电图和哇巴因激发时体表电位图的研究。
J Am Coll Cardiol. 2010 Feb 23;55(8):789-97. doi: 10.1016/j.jacc.2009.11.033.
8
Association between arrhythmogenic cardiomyopathy and Brugada syndrome - The influence of novel electrocardiographic features of Brugada syndrome.致心律失常性心肌病与Brugada综合征之间的关联——Brugada综合征新心电图特征的影响。
Int J Cardiol. 2015 Jul 15;191:301-2. doi: 10.1016/j.ijcard.2015.04.187. Epub 2015 Apr 23.
9
Acacetin suppresses the electrocardiographic and arrhythmic manifestations of the J wave syndromes.刺槐素可抑制J波综合征的心电图及心律失常表现。
PLoS One. 2020 Nov 24;15(11):e0242747. doi: 10.1371/journal.pone.0242747. eCollection 2020.
10
Letter by Santangeli et al regarding article, "High-density substrate mapping in Brugada syndrome: combined role of conduction and repolarization heterogeneities in arrhythmogenesis".桑坦杰利等人就题为《Brugada综合征的高密度基质标测：传导和复极异质性在心律失常发生中的联合作用》的文章所写的信
Circulation. 2010 Mar 23;121(11):e248; author reply e249. doi: 10.1161/CIR.0b013e3181d8d40d.
引用本文的文献
1
Beyond the Pleura: A Case Report of Type 1 Brugada Phenocopy in the Setting of Empyema.胸膜之外：脓胸情况下1型Brugada拟表型病例报告
Cureus. 2025 Aug 15;17(8):e90135. doi: 10.7759/cureus.90135. eCollection 2025 Aug.
2
Assessment of activation delay in the right ventricular outflow tract as a potential complementary diagnostic tool for Brugada Syndrome.评估右心室流出道激活延迟作为 Brugada 综合征潜在的辅助诊断工具。
Europace. 2025 Jun 3;27(6). doi: 10.1093/europace/euaf093.
3
Diagnosing Brugada syndrome: look for right ventricular outflow tract conduction delay.诊断布加综合征：寻找右心室流出道传导延迟。
Europace. 2025 Jun 3;27(6). doi: 10.1093/europace/euaf094.
4
Brugada syndrome.布加综合征
Nat Rev Dis Primers. 2025 May 29;11(1):38. doi: 10.1038/s41572-025-00622-5.
5
Brugada syndrome update.Brugada综合征最新进展。
Front Physiol. 2025 Jan 17;15:1520008. doi: 10.3389/fphys.2024.1520008. eCollection 2024.
6
Epicardial Ablation for Arrhythmogenic Disorders in Patients with Brugada Syndrome.布加综合征患者致心律失常性疾病的心外膜消融术
Biomedicines. 2024 Dec 26;13(1):27. doi: 10.3390/biomedicines13010027.
7
Artemisinin-Quinidine Combination for Suppressing Ventricular Tachyarrhythmia in an Ex Vivo Model of Brugada Syndrome.青蒿素-奎尼丁联合用药在 Brugada 综合征体外模型中抑制室性快速心律失常的研究
J Korean Med Sci. 2025 Jan 6;40(1):e2. doi: 10.3346/jkms.2025.40.e2.
8
Investigation of a Large Kindred Reveals Cardiac Calsequestrin () as a Cause of Brugada Syndrome.对一个大型家系的研究揭示，心脏肌浆网钙释放通道蛋白（）是 Brugada 综合征的一个致病原因。
Genes (Basel). 2024 Jun 21;15(7):822. doi: 10.3390/genes15070822.
9
A Novel Workflow for Electrophysiology Studies in Patients with Brugada Syndrome.一种 Brugada 综合征患者电生理研究的新工作流程。
Sensors (Basel). 2024 Jul 4;24(13):4342. doi: 10.3390/s24134342.
10
Intracellular ion accumulation in the genesis of complex action potential dynamics under cardiac diseases.细胞内离子积累在心脏疾病复杂动作电位动力学发生中的作用。
Phys Rev E. 2024 Feb;109(2-1):024410. doi: 10.1103/PhysRevE.109.024410.
本文引用的文献
1
Local depolarization abnormalities are the dominant pathophysiologic mechanism for type 1 electrocardiogram in brugada syndrome a study of electrocardiograms, vectorcardiograms, and body surface potential maps during ajmaline provocation.局部去极化异常是 1 型 Brugada 综合征心电图的主要病理生理机制：一项关于心电图、向量心电图和哇巴因激发时体表电位图的研究。
J Am Coll Cardiol. 2010 Feb 23;55(8):789-97. doi: 10.1016/j.jacc.2009.11.033.
2
SCN5A mutations and the role of genetic background in the pathophysiology of Brugada syndrome.SCN5A突变及遗传背景在Brugada综合征病理生理学中的作用。
Circ Cardiovasc Genet. 2009 Dec;2(6):552-7. doi: 10.1161/CIRCGENETICS.109.853374. Epub 2009 Sep 29.
3
Mechanism of right precordial ST-segment elevation in structural heart disease: excitation failure by current-to-load mismatch.结构性心脏病患者心前区右侧 ST 段抬高的机制：电流与负荷不匹配导致的激动失败。
Heart Rhythm. 2010;7(2):238-48. doi: 10.1016/j.hrthm.2009.10.007. Epub 2009 Oct 12.
4
Ventricular late potential in patients with apparently normal electrocardiogram; predictor of Brugada syndrome.心电图看似正常的患者的心室晚电位；Brugada综合征的预测指标。
Pacing Clin Electrophysiol. 2010 Mar;33(3):266-73. doi: 10.1111/j.1540-8159.2009.02621.x. Epub 2009 Dec 1.
5
Exercise-induced ECG changes in Brugada syndrome.布加综合征运动诱发的心电图改变。
Circ Arrhythm Electrophysiol. 2009 Oct;2(5):531-9. doi: 10.1161/CIRCEP.109.862441. Epub 2009 Aug 24.
6
Absence of pathognomonic or inflammatory patterns in cardiac biopsies from patients with Brugada syndrome.Brugada综合征患者心脏活检中缺乏特征性或炎症性模式。
Circ Arrhythm Electrophysiol. 2009 Feb;2(1):16-23. doi: 10.1161/CIRCEP.107.737882. Epub 2008 Dec 7.
7
Slow and discontinuous conduction conspire in Brugada syndrome: a right ventricular mapping and stimulation study.缓慢且不连续传导在Brugada综合征中共同起作用：一项右心室标测与刺激研究。
Circ Arrhythm Electrophysiol. 2008 Dec;1(5):379-86. doi: 10.1161/CIRCEP.108.790543. Epub 2008 Dec 2.
8
Drugs and Brugada syndrome patients: review of the literature, recommendations, and an up-to-date website (www.brugadadrugs.org).药物与 Brugada 综合征患者：文献回顾、建议和最新网站（www.brugadadrugs.org）。
Heart Rhythm. 2009 Sep;6(9):1335-41. doi: 10.1016/j.hrthm.2009.07.002. Epub 2009 Jul 8.
9
Differential effects of cardiac sodium channel mutations on initiation of ventricular arrhythmias in patients with Brugada syndrome.心脏钠通道突变对Brugada综合征患者室性心律失常起始的不同影响。
Heart Rhythm. 2009 Apr;6(4):487-92. doi: 10.1016/j.hrthm.2009.01.031. Epub 2009 Jan 31.
10
Functional effects of KCNE3 mutation and its role in the development of Brugada syndrome.KCNE3 突变的功能效应及其在 Brugada 综合征发生发展中的作用。
Circ Arrhythm Electrophysiol. 2008 Aug;1(3):209-18. doi: 10.1161/CIRCEP.107.748103.
Zotero 插件