Xu Tingting, Wang Shaokun, Wang Jiawen, Xing Jihong
Department of Emergency Medicine, The First Hospital of Jilin University, Changchun, Jilin, China.
Department of Nuclear Medicine, The First Hospital of Jilin University, Changchun, Jilin, China.
Front Physiol. 2025 Jan 17;15:1520008. doi: 10.3389/fphys.2024.1520008. eCollection 2024.
Brugada syndrome (BrS), a genetic disorder affecting cardiac ion channels, predominantly manifests due to mutations that impair the function of the Nav1.5 sodium channel's α-subunit. This condition, identified by Josep and Pedro Brugada, is often marked by symptoms such as syncope and episodes of polymorphic ventricular tachycardia (PVT) or ventricular fibrillation (VF). These arrhythmias, if not managed promptly, can escalate to sudden cardiac death (SCD), notably in patients whose cardiac structure appears normal. Given this, the prompt recognition and stratification of individuals at elevated risk are critical. This review elaborates on the current insights into BrS, focusing on recent diagnostic techniques, risk assessment strategies, and therapeutic advancements. It also critically examines ongoing controversies in the field.
布加综合征（BrS）是一种影响心脏离子通道的遗传性疾病，主要由损害Nav1.5钠通道α亚基功能的突变引起。这种疾病由何塞普（Josep）和佩德罗·布加（Pedro Brugada）发现，通常表现为晕厥以及多形性室性心动过速（PVT）或室颤（VF）发作等症状。这些心律失常如果不及时处理，可能会发展为心源性猝死（SCD），特别是在心脏结构看似正常的患者中。鉴于此，及时识别和分层高危个体至关重要。本综述阐述了目前对布加综合征的认识，重点关注近期的诊断技术、风险评估策略和治疗进展。它还对该领域目前存在的争议进行了批判性审视。
