妊娠合并妊娠期糖尿病和 2 型糖尿病孕妇的动脉僵硬度。

Maternal arterial stiffness in pregnancies complicated by gestational and type 2 diabetes mellitus.

机构信息

Department of Maternal-Fetal Medicine, Imperial College School of Medicine, Chelsea and Westminster Hospital, London, UK.

出版信息

Am J Obstet Gynecol. 2010 Sep;203(3):274.e1-7. doi: 10.1016/j.ajog.2010.06.021. Epub 2010 Jul 24.

DOI:10.1016/j.ajog.2010.06.021

PMID:20659727

Abstract

OBJECTIVE

We sought to investigate whether maternal arterial stiffness is altered in pregnant women with gestational diabetes mellitus (GDM) and type 2 diabetes compared to normoglycemic women.

STUDY DESIGN

We conducted a cross-sectional study involving 34 women with GDM and their controls (n = 34), and 34 women with type 2 diabetes and their controls (n = 34). Maternal arterial stiffness was assessed using applanation tonometry.

RESULTS

In patients with GDM, compared to their controls, augmentation index (a measure of arterial wave reflection) was higher (13.1 +/- 8.9% vs 0.7 +/- 11.4%; P < .001) and pulse wave velocity (PWV) (arterial stiffness of the carotid-femoral) was marginally increased (6 +/- 1.5 vs 5.4 +/- 0.6 m/s; P = .07). In type 2 diabetics, compared to their controls, both augmentation index and PWV were increased (11.5 +/- 11.4% vs 3.3 +/- 12.5%; P = .006, and 6.8 +/- 1.2 vs 5.6 +/- 1 m/s; P < .001). When all groups were considered together, there was a significant trend of increasing augmentation index (P = .001) and PWV (P < .001) from controls to those with GDM to type 2 diabetes.

CONCLUSION

Pregnancies complicated by GDM and type 2 diabetes are associated with increased maternal arterial stiffness.

摘要

目的

我们旨在研究与正常血糖孕妇相比，妊娠期糖尿病（GDM）和 2 型糖尿病孕妇的母体动脉僵硬度是否发生改变。

研究设计

我们进行了一项横断面研究，纳入了 34 例 GDM 孕妇及其对照组（n = 34），以及 34 例 2 型糖尿病孕妇及其对照组（n = 34）。采用平板压力测量法评估母体动脉僵硬度。

结果

与对照组相比，GDM 患者的增强指数（反映动脉波反射的指标）更高（13.1 +/- 8.9% vs 0.7 +/- 11.4%；P <.001），脉搏波速度（PWV）（颈-股动脉的动脉僵硬度）也略有增加（6 +/- 1.5 vs 5.4 +/- 0.6 m/s；P =.07）。与对照组相比，2 型糖尿病患者的增强指数和 PWV 均增加（11.5 +/- 11.4% vs 3.3 +/- 12.5%；P =.006，6.8 +/- 1.2 vs 5.6 +/- 1 m/s；P <.001）。当所有组一起考虑时，增强指数（P =.001）和 PWV（P <.001）从对照组到 GDM 再到 2 型糖尿病呈显著递增趋势。