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Subregional localization of the chromosome 21 loci D21S24 and D21S26 using physical mapping techniques.

作者信息

Van Hul W, Backhovens H, Van Camp G, Stinissen P, Cruts M, Wehnert A, Van Broeckhoven C

机构信息

Department of Biochemistry, Born-Bunge Foundation, University of Antwerp (UIA), Belgium.

出版信息

Hum Genet. 1991 Jun;87(2):109-11. doi: 10.1007/BF00204162.

DOI:10.1007/BF00204162
PMID:2066096
Abstract

We were able to refine the chromosomal position of two existing marker loci, using an extended chromosome 21 somatic cell hybrid panel. The locus D21S26 mapped in the region 21q11.2-q21.1, and the locus D21S24 in 21q22.1-q22.2. Physical and genetic analysis indicated that D21S26 is tightly linked to D21S13 and D21S16, two markers previously linked to familial Alzheimer's disease.

摘要

相似文献

1
Subregional localization of the chromosome 21 loci D21S24 and D21S26 using physical mapping techniques.
Hum Genet. 1991 Jun;87(2):109-11. doi: 10.1007/BF00204162.
2
Panel of aneuploid cell lines for physical mapping of the proximal long arm of human chromosome 21.用于人类21号染色体近端长臂物理图谱绘制的非整倍体细胞系面板。
Am J Med Genet Suppl. 1990;7:137-40. doi: 10.1002/ajmg.1320370728.
3
Exclusion of linkage to the pericentromeric region of chromosome 21 in the Canadian pedigree with familial Alzheimer disease.在患有家族性阿尔茨海默病的加拿大家系中排除与21号染色体着丝粒周围区域的连锁关系。
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4
Relative order and location of DNA sequences on chromosome 21 linked to familial Alzheimer disease.与家族性阿尔茨海默病相关的21号染色体上DNA序列的相对顺序和位置。
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Physical mapping of chromosome 21 DNA markers in Alzheimer's disease region using somatic cell hybrids.利用体细胞杂种对21号染色体上阿尔茨海默病区域的DNA标记进行物理图谱分析。
Somat Cell Mol Genet. 1990 May;16(3):241-9. doi: 10.1007/BF01233360.
6
A new HaeIII polymorphism at the D21S13 locus.
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7
Linkage of an Alzheimer disease susceptibility locus to markers on human chromosome 21.
Am J Med Genet. 1991 Sep 15;40(4):449-53. doi: 10.1002/ajmg.1320400415.
8
Identification of chromosome 21 DNA polymorphisms for genetic studies in Alzheimer's disease and Down syndrome.鉴定用于阿尔茨海默病和唐氏综合征基因研究的21号染色体DNA多态性。
Hum Genet. 1991 Oct;87(6):649-53. doi: 10.1007/BF00201718.
9
Linkage analysis of familial Alzheimer disease, using chromosome 21 markers.利用21号染色体标记对家族性阿尔茨海默病进行连锁分析。
Am J Hum Genet. 1991 Mar;48(3):563-83.
10
Physical mapping around the Alzheimer disease locus on the proximal long arm of chromosome 21.21号染色体长臂近端阿尔茨海默病基因座周围的物理图谱。
Am J Hum Genet. 1990 Feb;46(2):316-22.

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Analysis of human chromosome 21: correlation of physical and cytogenetic maps; gene and CpG island distributions.人类21号染色体分析：物理图谱与细胞遗传图谱的相关性；基因和CpG岛分布
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Assignment of the Charcot-Marie-Tooth neuropathy type 1 (CMT 1a) gene to 17p11.2-p12.将1型遗传性运动感觉神经病（CMT 1a）基因定位于17p11.2 - p12。
Am J Hum Genet. 1990 Oct;47(4):680-5.
9
PCR detection of two RFLP's at the D21S13 locus.在D21S13基因座通过聚合酶链式反应检测两种限制性片段长度多态性
Nucleic Acids Res. 1990 Jun 25;18(12):3672. doi: 10.1093/nar/18.12.3672.
10
An informative MspI polymorphism detected at the D21S16 locus.在D21S16位点检测到一个信息丰富的MspI多态性。
Hum Genet. 1990 Jun;85(1):140. doi: 10.1007/BF00276344.