Feinstein A, Yorav S, Movshovitz M, Schewach-Millet M
Department of Dermatology, Chaim Sheba Medical Center, Tel Hashomer, Israel.
Int J Dermatol. 1991 May;30(5):347-51. doi: 10.1111/j.1365-4362.1991.tb03873.x.
A family in which two sisters are affected by pemphigus is described. Literature research has revealed the presence of 25 families, comprising 53 patients, in which pemphigus existed in more than one member. The relationships between those affected were mainly parent-child or sibling-sibling. Pemphigus was found to be associated with specific HLA antigens: A26, Bw38, DRw4, and additionally occurred with a higher frequency in certain ethnic groups. The variety of etiologic factors in the pathogenesis of pemphigus is discussed and the significance of a genetic role elucidated.
本文描述了一个有两名姐妹患天疱疮的家庭。文献研究显示，有25个家庭共53名患者，其中不止一名家庭成员患有天疱疮。患者之间的关系主要是亲子关系或兄弟姐妹关系。发现天疱疮与特定的HLA抗原相关：A26、Bw38、DRw4，并且在某些种族群体中出现的频率更高。本文讨论了天疱疮发病机制中各种病因，并阐明了遗传作用的重要性。
