Wilson C, Wojnarowska F, Mehra N K, Pasricha J S
Department of Dermatology, Churchill Hospital, Oxford, UK.
Dermatology. 1994;189 Suppl 1:108-10. doi: 10.1159/000246946.
A study of pemphigus in New Delhi, India, and Oxford, UK, was undertaken including 20 patients in Oxford and 50 in New Delhi. Data included clinical and histological subtypes and socio-economic data; patients were HLA typed. In New Delhi pemphigus vulgaris predominated, but in Oxford pemphigus vulgaris and pemphigus foliaceus have equal prevalence. Disease distribution with sex was the same, but age at onset was significantly lower in New Delhi (p = 0.0019). HLA typing in pemphigus vulgaris patients revealed a significant reduction in HLA-DR2 in New Delhi (p = 0.0008) and Oxford (p = 0.09). A small increase in HLA-DR1 and -DR4 was found in both groups and, in males only, a subtle increase in HLA-DR6 and reduction in HLA-DR3. No differences were found in the class I antigens. Thus there are striking differences in the types of pemphigus between the two populations, yet the genetic predisposition is the same.
一项针对印度新德里和英国牛津天疱疮的研究展开，牛津有20名患者，新德里有50名患者。数据包括临床和组织学亚型以及社会经济数据；对患者进行了HLA分型。在新德里，寻常型天疱疮占主导，但在牛津，寻常型天疱疮和落叶型天疱疮的患病率相当。疾病的性别分布相同，但新德里的发病年龄显著更低（p = 0.0019）。寻常型天疱疮患者的HLA分型显示，新德里（p = 0.0008）和牛津（p = 0.09）的HLA-DR2均显著减少。两组中HLA-DR1和-DR4均有小幅增加，仅在男性中，HLA-DR6有细微增加，HLA-DR3减少。在I类抗原方面未发现差异。因此，这两个人群中天疱疮的类型存在显著差异，但遗传易感性相同。
