Department of Endocrinology and Metabolism, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai Clinical Center of Diabetes, Shanghai Diabetes Institute, China.
Diabetes Metab Res Rev. 2010 Sep;26(6):481-9. doi: 10.1002/dmrr.1107.
The 10-g Semmes-Weinstein monofilament and 128-Hz tuning fork examinations are considered simple and effective screening instruments for diabetic peripheral neuropathy. This study investigated the prevalence of diabetic peripheral neuropathy of combining both methods in type 2 diabetic outpatients in Chinese urban hospitals.
Pressure sensation and vibration perception were randomly screened using 10-g Semmes-Weinstein monofilament and 128-Hz tuning fork in type 2 diabetic outpatients from 12 centres in 8 Chinese cities in a randomized, multicentre epidemiological study. The prevalence and treatment status of neuropathy were assessed, and relevant risk factors were analysed.
A total of 1197 outpatients were screened and 1193 were enrolled in this study, including 1067 known cases of diabetes (KDM group) and 126 newly diagnosed cases of diabetes (NDM group). Screening results showed that the prevalence of perception defects was 17.02% in the total population, 18.28% in the known DM group and 6.35% in the new DM group, respectively. The frequency of previous diabetic peripheral neuropathy examination was only 32% in the known DM group and 31.75% in the new DM group. Thirty-two percent of known DM patients with diabetic peripheral neuropathy did not receive any treatment formerly. It also revealed that there was a region-wise difference in prevalence of diabetic peripheral neuropathy, and it increased with age and diabetic duration. Retinopathy, HbA(1c), diabetes duration and age were independent risk factors for diabetic peripheral neuropathy.
The screening and treatment rate of diabetic peripheral neuropathy is low in China. The prevalence of diabetic peripheral neuropathy in type 2 diabetic outpatients in Chinese city hospitals is 17.2%. Diabetic retinopathy is an independent risk factor for diabetic peripheral neuropathy.
10g 丝触觉检查和 128Hz 音叉检查被认为是筛查糖尿病周围神经病变的简单有效的方法。本研究调查了中国城市医院 2 型糖尿病门诊患者联合使用这两种方法的糖尿病周围神经病变的患病率。
在一项多中心随机流行病学研究中，我们在 12 个中心的中国 8 个城市的 2 型糖尿病门诊患者中，随机使用 10g 丝触觉检查和 128Hz 音叉检查筛查压力感觉和振动觉。评估了神经病的患病率和治疗状况，并分析了相关的危险因素。
共筛查 1197 例门诊患者，1193 例患者入组本研究，包括 1067 例已知糖尿病患者（KDM 组）和 126 例新诊断的糖尿病患者（NDM 组）。筛查结果显示，总人群中感觉缺失的患病率为 17.02%，已知 DM 组为 18.28%，新 DM 组为 6.35%。在已知 DM 组中，仅有 32%的患者曾进行过糖尿病周围神经病检查，在新 DM 组中这一比例为 31.75%。32%的已知糖尿病周围神经病变患者未接受任何治疗。研究还发现，糖尿病周围神经病变的患病率存在地域差异，且随年龄和糖尿病病程的增加而增加。视网膜病变、HbA1c、糖尿病病程和年龄是糖尿病周围神经病变的独立危险因素。
中国对糖尿病周围神经病变的筛查和治疗率较低。中国城市医院 2 型糖尿病门诊患者的糖尿病周围神经病变患病率为 17.2%。糖尿病视网膜病变是糖尿病周围神经病变的独立危险因素。
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