Department of Endocrinology and Metabolism, HuaShan Hospital, Shanghai 200040, China.
Diabetes Res Clin Pract. 2010 Jun;88(3):289-94. doi: 10.1016/j.diabres.2010.02.002. Epub 2010 Mar 31.
To determine the prevalence of diabetic peripheral neuropathy (DPN) and risk factors associated with DPN in type 2 diabetic patients.
435 diabetic patients were evaluated on complete foot examination. Body mass measurements, resting blood pressure, fasting blood measures, urinary albumin-to-creatinine ratio (ACR) and the digitally stored fundus images were investigated.
(1) The prevalence of DPN was 61.8% among the Chinese patients diagnosed with type 2 diabetes aged over 30 in the Shanghai downtown, 59.1% with vibration perception threshold > or =25 V and 13.8% with inability to feel the monofilament. (2) DPN was significantly associated with age (beta: 0.068, S.E.: 0.013, OR: 1.070, CI: 1.043-1.098, P<0.001) and HbA1c (beta: 0.224, S.E.: 0.081, OR: 1.251, CI: 1.067-1.466, P=0.006) by a logistic regression analysis. (3) The percentage of diabetic retinopathy (DR) in the DPN group (26.5%) was significantly higher than that in the non-DPN group (15.2%). (4) The percentage of macroalbuminuria in the DPN group (9.0%) was significantly higher than that in the non-DPN group (1.8%).
The prevalence of DPN observed in the Chinese patients diagnosed with type 2 diabetes aged over 30 in the Shanghai downtown reached up to 61.8% though the observations in our study might be representative of the diabetic patients of the Shanghai downtown.
确定上海市区 30 岁以上 2 型糖尿病患者中糖尿病周围神经病变（DPN）的患病率及其相关危险因素。
对 435 例糖尿病患者进行全面足部检查，测量体重、静息血压、空腹血糖、尿白蛋白与肌酐比值（ACR），并存储眼底数字图像。
（1）上海市区 30 岁以上 2 型糖尿病患者中 DPN 的患病率为 61.8%，振动感觉阈值>或=25 V 者占 59.1%，不能感知单丝者占 13.8%。（2）Logistic 回归分析显示，DPN 与年龄（β：0.068，SE：0.013，OR：1.070，CI：1.043-1.098，P<0.001）和糖化血红蛋白（HbA1c）（β：0.224，SE：0.081，OR：1.251，CI：1.067-1.466，P=0.006）显著相关。（3）DPN 组的糖尿病视网膜病变（DR）发生率（26.5%）显著高于非 DPN 组（15.2%）。（4）DPN 组的大量白蛋白尿发生率（9.0%）显著高于非 DPN 组（1.8%）。
上海市区 30 岁以上 2 型糖尿病患者的 DPN 患病率高达 61.8%，但本研究的观察结果可能代表了上海市区的糖尿病患者。
