Alshammari Nawaf A, Alodhayani Abdulaziz A, Joy Salini S, Isnani Arthur, Mujammami Muhammad, Alfadda Assim A, Siddiqui Khalid
University Diabetes Center, King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia.
King Salman Specialist Hospital, Diabetes and Endocrine Center, Hail Health Cluster, Hail, Hail Region, Saudi Arabia.
Diabetes Metab Syndr Obes. 2022 Sep 28;15:3007-3014. doi: 10.2147/DMSO.S364933. eCollection 2022.
Neuropathy is the most common microvascular complications among diabetic patients. Diabetic peripheral neuropathy (DPN) is the predominant variety which may associate with increased in mortality and morbidity among type 2 diabetes mellitus (T2DM).
To assess the prevalence of diabetic peripheral neuropathy and its correlation with risk factors among T2DM.
This was a cross-sectional retrospective study, data was collected from a previous cohort study conducted at the University Diabetes Center, King Saud University Medical City (KSUMC), King Saud University, Riyadh, Saudi Arabia. The data of T2DM patients were collected from case report form, included demographic data, history of chronic diabetes neuropathy, and laboratory reports. Statistical analysis includes Student`s test, chi square test, and Pearson correlation and logistic regression were performed.
A total of 430 patients with T2DM data was collected and analyzed, and of them 54% were females, with the mean age of 55.88 years. The prevalence of diabetic neuropathy among study participants were 40.2%, and 73.3% of them having the subtype polyneuropathy. The mean BMI; = 0.006, FBS; < 0.001, HbA1c; < 0.001, cholesterol = 0.001, LDL; < 0.001, and triglyceride; < 0.001 levels were a significantly higher among participants with diabetic neuropathy than without neuropathy. The male gender (Risk Ratio: 1.294, 95% CI:1.090, 1.536) = 0.003, fasting blood glucose (Risk Ratio: 1.157, 95% CI:1.051, 1.273) = 0.003 Cholesterol (Risk Ratio: 1.588, 95% CI:1.174, 2.147) = 0.003, triglyceride (Risk Ratio: 1.290, 95% CI:1.086, 1.538), = 0.004, and LDL (Risk Ratio: 1.299, 95% CI:1.073, 1.574), = 0.007) were found to be significant risk factors for DPN.
DPN is highly prevalent among T2DM patients in Saudi Arabia. Poor glycemic control and hyperlipidemia were associated with significantly higher risk for DPN patients among T2DM.
神经病变是糖尿病患者中最常见的微血管并发症。糖尿病周围神经病变（DPN）是最主要的类型，可能与2型糖尿病（T2DM）患者死亡率和发病率的增加有关。
评估T2DM患者中糖尿病周围神经病变的患病率及其与危险因素的相关性。
这是一项横断面回顾性研究，数据来自沙特阿拉伯利雅得国王沙特大学医学城国王沙特大学糖尿病中心之前进行的一项队列研究。T2DM患者的数据从病例报告表中收集，包括人口统计学数据、慢性糖尿病神经病变病史和实验室报告。进行了统计分析，包括学生t检验、卡方检验、Pearson相关性分析和逻辑回归分析。
共收集并分析了430例T2DM患者的数据，其中54%为女性，平均年龄为55.88岁。研究参与者中糖尿病神经病变的患病率为40.2%，其中73.3%为多神经病变亚型。糖尿病神经病变患者的平均体重指数（BMI）；P = 0.006，空腹血糖（FBS）；P < 0.001，糖化血红蛋白（HbA1c）；P < 0.001，胆固醇；P = 0.001，低密度脂蛋白（LDL）；P < 0.001，甘油三酯；P < 0.001水平显著高于无神经病变的参与者。男性（风险比：1.294，95%置信区间：1.090，1.536）；P = 0.003，空腹血糖（风险比：1.157，95%置信区间：1.051，1.273）；P = 0.003，胆固醇（风险比：1.588，95%置信区间：1.174，2.147）；P = 0.003，甘油三酯（风险比：1.290，95%置信区间：1.086，1.538）；P = 0.004，以及LDL（风险比：1.299，95%置信区间：1.073，1.574）；P = 0.007）被发现是DPN的显著危险因素。
在沙特阿拉伯，DPN在T2DM患者中高度流行。血糖控制不佳和高脂血症与T2DM患者中DPN的显著更高风险相关。
