Clapp R W, Cupples L A, Colton T, Ozonoff D M
Boston University School of Public Health, Section on Epidemiology and Biostatistics, MA 02118.
Int J Epidemiol. 1991 Mar;20(1):7-12. doi: 10.1093/ije/20.1.7.
This surveillance study is a follow-up to previous findings of elevated soft tissue sarcoma mortality in Massachusetts Vietnam veterans compared to other veterans. The roster of veterans was compiled from Massachusetts residents who received a state bonus for military service in the period 1958-1973. This computerized list was linked to the central files of the Massachusetts Cancer Registry and cases diagnosed between 1982 and 1988 were identified. Odds ratios (ORs) for several cancer sites were computed; only that for soft tissue sarcoma incidence was significantly elevated in Vietnam veterans compared to other veterans (OR = 3.08; 95% confidence interval: (CI) 1.07-8.73). Kaposi's sarcoma cases who were also AIDS patients were excluded from the analysis. Non-Hodgkin's lymphoma was also investigated but was not significantly elevated in these surveillance data. Sources of bias are discussed and recommendations for continued surveillance and follow-up studies are made.
这项监测研究是对之前一项研究结果的后续跟进，该研究发现，与其他退伍军人相比，马萨诸塞州越战退伍军人的软组织肉瘤死亡率有所升高。退伍军人名单是根据1958年至1973年期间在马萨诸塞州因服兵役而获得州奖金的居民编制的。这份计算机化名单与马萨诸塞州癌症登记处的中央档案相链接，并确定了1982年至1988年间诊断出的病例。计算了几个癌症部位的比值比（OR）；与其他退伍军人相比，只有越战退伍军人的软组织肉瘤发病率显著升高（OR = 3.08；95%置信区间：（CI）1.07 - 8.73）。同时也是艾滋病患者的卡波西肉瘤病例被排除在分析之外。还对非霍奇金淋巴瘤进行了调查，但在这些监测数据中其发病率没有显著升高。文中讨论了偏差来源，并针对持续监测和后续研究提出了建议。
