School of Biology, Georgia Institute of Technology, Atlanta, GA, USA.
FEMS Microbiol Ecol. 2010 Dec;74(3):485-99. doi: 10.1111/j.1574-6941.2010.00937.x.
An increase in the frequency of seafood-borne gastroenteritis in humans and Vibrio-related disease of fish and invertebrates has generated interest in the ecology of disease-causing Vibrios and the mechanisms driving their evolution. Genome sequencing studies have indicated a substantial contribution of horizontal gene transfer (HGT) to the evolution of Vibrios. Of particular interest is the contribution of HGT to the evolution of Vibrios pathogens and the adaptation of disease-causing Vibrios for survival in diverse environments. In this review, we discuss the diversity and distribution of mobile genetic elements (MGEs) isolated from Vibrios and the contribution of these elements to the expansion of the ecological and pathogenic niches of the host strain. Much of the research on Vibrio MGEs has focused on understanding phages and plasmids and we will primarily discuss the evolution of these elements and also briefly highlight the other diverse elements characterized from Vibrios, which includes genomic islands and conjugative elements.
人类因食用海鲜而导致的肠胃炎以及鱼类和无脊椎动物感染相关病菌的频率增加，引起了人们对致病菌弧菌的生态以及驱动其进化的机制的兴趣。基因组测序研究表明，水平基因转移（HGT）对弧菌的进化做出了重大贡献。特别值得关注的是，HGT 对弧菌病原体进化以及致病菌适应不同环境的生存能力的贡献。在这篇综述中，我们讨论了从弧菌中分离出的可移动遗传因子（MGE）的多样性和分布，以及这些因子对宿主菌株生态和致病生态位扩展的贡献。对弧菌 MGE 的大部分研究都集中在理解噬菌体和质粒上，我们将主要讨论这些因子的进化，也简要介绍从弧菌中特征化的其他不同因子，包括基因组岛和可接合性因子。
