Molecular characterization and antibiotic resistance of strains isolated from patients with diarrhea in Korea between the years 2007 and 2022.

UNLABELLED

To investigate the molecular characteristics and antibiotic resistance of isolates from patients with diarrhea in Korea, 327 strains were collected between 2007 and 2022. The presence of staphylococcal enterotoxin (SE) and toxic shock syndrome toxin-1 (TSST-1) genes in isolates was determined by PCR. The highest expression of the TSST-1 gene was found in the GIMNO type (43.1% of GIMNO type). GIMNO type (Type I) refers to each staphylococcal enterotoxin (SE) gene gene (initials of genes): G = ; I = ; M = ; N = ; O = . Moreover, Type I isolates showed a significantly higher resistance to most antibiotics. A total of 195 GIMNO-type strains were analyzed using multilocus sequence typing (MLST), and 18 unique sequence types (STs) were identified. The most frequent sequence type was ST72 (36.9%), followed by ST5 (22.1%) and ST30 (16.9%). Interestingly, ST72 strains showed a higher prevalence of MRSA than the other STs. In conclusion, our results were the first reported for strains in Korea, which significantly expanded genotype information for the surveillance of pathogenic and may provide important epidemiological information to resolve several infectious diseases caused by .

SUPPLEMENTARY INFORMATION

The online version contains supplementary material available at 10.1007/s10068-023-01478-9.