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与小鼠颞浅静脉反复出血相关的发病率和死亡率。

Morbidity and mortality rates associated with serial bleeding from the superficial temporal vein in mice.

机构信息

Department of Molecular and Comparative Pathobiology, Johns Hopkins School of Medicine, Baltimore, MD, USA.

出版信息

Lab Anim (NY). 2010 Aug;39(8):236-40. doi: 10.1038/laban0810-236.

DOI:10.1038/laban0810-236
PMID:20664572
Abstract

The authors reviewed 3 years' worth of records of superficial temporal vein phlebotomies that had been carried out in Balb/c mice. Mice that had undergone the phlebotomies had a mortality rate of approximately 1% (4 deaths per 490 procedures). Although the mice were being used in a drug study, necropsy and blood assay results suggest that the four deaths were caused by failure to stop the bleeding after the phlebotomies. The authors offer suggestions for improving morbidity and mortality associated with temporal vein phlebotomy.

摘要

作者回顾了 3 年来在 Balb/c 小鼠中进行的颞浅静脉采血的记录。接受采血的小鼠死亡率约为 1%(490 次手术中有 4 例死亡)。尽管这些小鼠被用于药物研究,但尸检和血液检测结果表明,这 4 例死亡是由于采血后未能止血导致的。作者就如何降低与颞浅静脉采血相关的发病率和死亡率提出了建议。

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