Department of Obstetrics and Gynecology, NYU, New York, NY, USA.
J Assist Reprod Genet. 2010 Nov;27(11):613-7. doi: 10.1007/s10815-010-9455-y. Epub 2010 Jul 28.
to compare pre-cryo data from oocyte cryopreservation (OC) cycles performed for malignancy (MED) vs. elective deferment of reproduction (DR) or oocyte donation (OD).
all patients were ≤40 y and underwent standard ovarian stimulation and retrieval. Prior to OC, meiotic spindle (MS) and zona pellucida (ZP) retardance was measured using digital polarized light microscopy (DPLM).
of 130 OC cycles, 49 were for MED, 73 for DR, and 8 for OD. Cycles completed for MED had an average of 9 ±1 spindle-positive oocytes with a mean MS retardance of 1.2 ± 02 nm and ZP retardance of 2.1 ± .06 nm, which was clinically comparable to the other groups.
women with malignancy can achieve adequate ovarian response and similar oocyte parameters to those of women undergoing fertility preservation for non-cancer indications. Such information, coupled with the ability to noninvasively study oocyte dynamics, may improve the counseling of cancer patients seeking fertility preservation.
比较因恶性肿瘤（MED）而行卵母细胞冷冻保存（OC）与因选择性推迟生育（DR）或卵母细胞捐赠（OD）而行 OC 的周期的预冻存数据。
所有患者均≤40 岁，接受标准卵巢刺激和取卵。在 OC 之前，使用数字偏光显微镜（DPLM）测量减数分裂纺锤体（MS）和透明带（ZP）延迟。
在 130 个 OC 周期中，49 个用于 MED，73 个用于 DR，8 个用于 OD。完成的 MED 周期平均有 9±1 个 MS 阳性卵母细胞，MS 延迟平均值为 1.2±02nm，ZP 延迟平均值为 2.1±0.06nm，与其他组相当。
患有恶性肿瘤的女性可以获得足够的卵巢反应和类似的卵母细胞参数，与因非癌症指征而进行生育力保存的女性相当。此类信息，加上能够对卵母细胞动力学进行非侵入性研究，可能会改善寻求生育力保存的癌症患者的咨询。
