Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Bos 281, 171 77 Stockholm, Sweden.
Genome Med. 2010 Jul 29;2(7):45. doi: 10.1186/gm166.
Prostate cancer is one of the most heritable cancers in men, and recent genome-wide association studies have revealed numerous genetic variants associated with disease. The risk variants identified using case-control designs that compared unaffected individuals with all types of patients with prostate cancer show little or no ability to discriminate between indolent and fatal forms of this disease. This suggests different genetic components are involved in the initiation as compared with the prognosis of prostate cancer. Future studies contrasting patients with more and less aggressive disease, and exploring association with disease progression and prognosis, should be more effective in detecting genetic risk factors for prostate cancer outcome.
前列腺癌是男性中最具遗传性的癌症之一,最近的全基因组关联研究揭示了许多与疾病相关的遗传变异。使用病例对照设计来识别风险变异,将未受影响的个体与所有类型的前列腺癌患者进行比较,这些设计显示出在区分疾病的惰性和致命形式方面的能力很小或没有。这表明在前列腺癌的发生与预后方面涉及不同的遗传成分。未来的研究对比更具侵袭性和侵袭性较小的患者,并探讨与疾病进展和预后的关联,应该更有效地检测前列腺癌结局的遗传风险因素。