全基因组关联研究和重复研究确定了与前列腺癌易感性相关的四个变异。
Genome-wide association and replication studies identify four variants associated with prostate cancer susceptibility.
作者信息
Gudmundsson Julius, Sulem Patrick, Gudbjartsson Daniel F, Blondal Thorarinn, Gylfason Arnaldur, Agnarsson Bjarni A, Benediktsdottir Kristrun R, Magnusdottir Droplaug N, Orlygsdottir Gudbjorg, Jakobsdottir Margret, Stacey Simon N, Sigurdsson Asgeir, Wahlfors Tiina, Tammela Teuvo, Breyer Joan P, McReynolds Kate M, Bradley Kevin M, Saez Berta, Godino Javier, Navarrete Sebastian, Fuertes Fernando, Murillo Laura, Polo Eduardo, Aben Katja K, van Oort Inge M, Suarez Brian K, Helfand Brian T, Kan Donghui, Zanon Carlo, Frigge Michael L, Kristjansson Kristleifur, Gulcher Jeffrey R, Einarsson Gudmundur V, Jonsson Eirikur, Catalona William J, Mayordomo Jose I, Kiemeney Lambertus A, Smith Jeffrey R, Schleutker Johanna, Barkardottir Rosa B, Kong Augustine, Thorsteinsdottir Unnur, Rafnar Thorunn, Stefansson Kari
机构信息
deCODE Genetics, Reykjavik, Iceland.
出版信息
Nat Genet. 2009 Oct;41(10):1122-6. doi: 10.1038/ng.448. Epub 2009 Sep 20.
We report a prostate cancer genome-wide association follow-on study. We discovered four variants associated with susceptibility to prostate cancer in several European populations: rs10934853[A] (OR = 1.12, P = 2.9 x 10(-10)) on 3q21.3; two moderately correlated (r2 = 0.07) variants, rs16902094[G] (OR = 1.21, P = 6.2 x 10(-15)) and rs445114[T] (OR = 1.14, P = 4.7 x 10(-10)), on 8q24.21; and rs8102476[C] (OR = 1.12, P = 1.6 x 10(-11)) on 19q13.2. We also refined a previous association signal on 11q13 with the SNP rs11228565[A] (OR = 1.23, P = 6.7 x 10(-12)). In a multivariate analysis using 22 prostate cancer risk variants typed in the Icelandic population, we estimated that carriers in the top 1.3% of the risk distribution are at a 2.5 times greater risk of developing the disease than members of the general population.
我们报告了一项前列腺癌全基因组关联后续研究。我们在几个欧洲人群中发现了四个与前列腺癌易感性相关的变异：位于3q21.3的rs10934853[A]（比值比=1.12，P=2.9×10⁻¹⁰）；位于8q24.21的两个中度相关（r²=0.07）的变异，rs16902094[G]（比值比=1.21，P=6.2×10⁻¹⁵）和rs445114[T]（比值比=1.14，P=4.7×10⁻¹⁰）；以及位于19q13.2的rs8102476[C]（比值比=1.12，P=1.6×10⁻¹¹）。我们还通过单核苷酸多态性rs11228565[A]（比值比=1.23，P=6.7×10⁻¹²）对先前在11q13上的关联信号进行了优化。在一项对冰岛人群中分型的22个前列腺癌风险变异进行的多变量分析中，我们估计，处于风险分布前1.3%的携带者患该病的风险比普通人群成员高2.5倍。
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