Desroches Christie E, Busto Macarena, Riedl Craig A L, Mackay Trudy F C, Sokolowski Marla B
Biology Department, University of Toronto at Mississauga, Mississauga, ON, Canada L5C 1J6.
Genet Res (Camb). 2010 Jun;92(3):167-74. doi: 10.1017/S0016672310000194.
Drosophila melanogaster, like other organisms, move and orient themselves in response to the earth's gravitational force. The ability to sense and respond to gravity is essential for an organism to navigate and thrive in its environment. The genes underlying this behaviour in Drosophila remain elusive. Using 88 recombinant inbred lines, we have identified four quantitative trait loci (QTLs) that contribute to adult gravitaxis (geotaxis) behaviour in Drosophila. Candidate genes of interest were selected from the QTLs of highest significance based on their function in chordotonal organ formation. Quantitative complementation tests with these candidate genes revealed a role for skittles in adult gravitaxis behaviour in D. melanogaster.
与其他生物一样，黑腹果蝇会根据地球引力移动并确定自身方向。感知和响应重力的能力对于生物体在其环境中导航和生存至关重要。果蝇中这种行为背后的基因仍然难以捉摸。我们使用88个重组近交系，鉴定出了四个影响果蝇成虫重力趋性（地趋性）行为的数量性状基因座（QTL）。基于其在弦音器官形成中的功能，从最显著的QTL中选择了感兴趣的候选基因。对这些候选基因进行的定量互补试验揭示了skittles在黑腹果蝇成虫重力趋性行为中的作用。
