Bakirkoy State Hospital for Mental Health and Neurological Disorders, Alcohol and Drug Research, Treatment and Training Center (AMATEM), Istanbul, Turkey.
Psychiatry Res. 2011 Mar 30;186(1):85-90. doi: 10.1016/j.psychres.2010.07.004. Epub 2010 Jul 27.
The aim of this study was to investigate the impact of lifetime posttraumatic stress disorder (PTSD), dissociation and a history of childhood trauma on quality of life (QoL) among men with alcohol dependency. A consecutive series of alcohol-dependent men (N=156) admitted to an inpatient treatment unit were screened using the Michigan Alcoholism Screening Test, the Clinician Administered PTSD Scale, the Dissociative Experiences Scale, and the Childhood Trauma Questionnaire. QoL was assessed using the Medical Outcomes Study Short-Form 36-item health survey. Fifty (32.1%) patients had lifetime diagnosis of PTSD. Besides problems related to severity of alcohol use, the lifetime PTSD group was impaired on several physical and mental components of QoL. While the lifetime PTSD group and remaining patients did not differ on reports of childhood trauma and dissociation, in lifetime PTSD group, dissociative patients had higher scores of childhood emotional abuse than those of the non-dissociative patients. In multivariate covariance analysis, both dissociation and lifetime PTSD predicted impairment in physical functioning, general health, vitality, and mental health components of QoL. Among alcohol-dependent men with lifetime PTSD, a history of childhood emotional abuse contributes to impairment of QoL through its relationship with dissociation.
本研究旨在探讨创伤后应激障碍（PTSD）、分离和童年创伤史对酒精依赖男性生活质量（QoL）的影响。连续收治的 156 例酒精依赖男性患者在入组时采用密歇根酒精筛查测试、临床医生管理 PTSD 量表、分离体验量表和儿童创伤问卷进行筛查。采用健康调查简表 36 项健康研究（Medical Outcomes Study Short-Form 36-item health survey）评估 QoL。50 例（32.1%）患者存在 PTSD 终生诊断。除了与酒精使用严重程度相关的问题外，PTSD 终生组在 QoL 的多个生理和心理成分上都存在受损。尽管 PTSD 终生组和其余患者在童年创伤和分离报告上没有差异，但在 PTSD 终生组中，分离患者的童年情感虐待得分高于非分离患者。在多元协方差分析中，分离和 PTSD 终生均预测生理功能、总体健康、活力和心理健康成分的 QoL 受损。在有 PTSD 终生史的酒精依赖男性中，童年情感虐待史通过与分离的关系导致 QoL 受损。
