Hall C B, Douglas R G, Simons R L, Geiman J M
J Pediatr. 1978 Jul;93(1):28-32. doi: 10.1016/s0022-3476(78)80594-0.
To better understand the recovery process of infants with lower respiratory tract disease due to respiratory syncytial virus, the production of interferon by 129 children (ages 10 days to 24 months) with RSV infection was compared to that of 20 children with influenza (ages 1 to 36 months), and 37 children with parainfluenza virus infection (ages 4 to 66 months). Interferon assays of 285 nasal washes from children with RSV revealed that interferon production occurred in only 5 (4%) of the children. Significantly more children infected with infleunza virus, 55% (P less than 0.001), and parainfluenza virus, 30% (P less than 0.001), produced interferon. In addition, the quantity of interferon produced by children with RSV (geometric mean titer = 2) was significantly less than that of children with influenza (GMT = 26.8, P less than 0.001) and parainfluenza virus (GMT = 23.5, P less than 0.001). In the children infected with RSV, in constrast to those with influenza, interferon detection was not associated with diminished shedding of virus.
为了更好地了解呼吸道合胞病毒所致下呼吸道疾病患儿的恢复过程，将129例呼吸道合胞病毒感染患儿（年龄10天至24个月）的干扰素生成情况与20例流感患儿（年龄1至36个月）及37例副流感病毒感染患儿（年龄4至66个月）进行了比较。对呼吸道合胞病毒感染患儿的285份鼻腔灌洗液进行的干扰素检测显示，仅5例（4%）患儿产生了干扰素。感染流感病毒的患儿中产生干扰素的比例显著更高，为55%（P<0.001），感染副流感病毒的患儿中这一比例为30%（P<0.001）。此外，呼吸道合胞病毒感染患儿产生的干扰素量（几何平均滴度=2）显著低于流感患儿（几何平均滴度=26.8，P<0.001）和副流感病毒感染患儿（几何平均滴度=23.5，P<0.001）。与流感患儿不同，在呼吸道合胞病毒感染患儿中，干扰素检测与病毒排出减少无关。
