干扰素——对呼吸道病毒免疫反应的影响

Interferons-Implications in the Immune Response to Respiratory Viruses.

作者信息

Bergeron Harrison C, Hansen Matthew R, Tripp Ralph A

机构信息

Department of Infectious Diseases, University of Georgia College of Veterinary Medicine, Athens, GA 30605, USA.

出版信息

Microorganisms. 2023 Aug 29;11(9):2179. doi: 10.3390/microorganisms11092179.

DOI:10.3390/microorganisms11092179

PMID:37764023

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10535750/

Abstract

Interferons (IFN) are an assemblage of signaling proteins made and released by various host cells in response to stimuli, including viruses. Respiratory syncytial virus (RSV), influenza virus, and SARS-CoV-2 are major causes of respiratory disease that induce or antagonize IFN responses depending on various factors. In this review, the role and function of type I, II, and III IFN responses to respiratory virus infections are considered. In addition, the role of the viral proteins in modifying anti-viral immunity is noted, as are the specific IFN responses that underly the correlates of immunity and protection from disease.

摘要

干扰素（IFN）是由各种宿主细胞在受到包括病毒在内的刺激后产生并释放的一组信号蛋白。呼吸道合胞病毒（RSV）、流感病毒和严重急性呼吸综合征冠状病毒2（SARS-CoV-2）是呼吸道疾病的主要病因，它们根据各种因素诱导或拮抗干扰素反应。在这篇综述中，我们考虑了I型、II型和III型干扰素反应在呼吸道病毒感染中的作用和功能。此外，还提到了病毒蛋白在改变抗病毒免疫中的作用，以及作为免疫和疾病防护相关性基础的特定干扰素反应。