Poliakova T G, Demidova S A, Bikbulatov R M, Ivanova L A, Krylov V F
Vopr Virusol. 1985 May-Jun;30(3):299-302.
Virological examinations of the cerebrospinal fluid and nasopharyngeal washings from 96 patients with influenza and other acute respiratory viral diseases and of the autopsy material from 14 patients who had had symptoms of the involvement of the central nervous system permitted isolation of respiratory viruses and detection of viral antigens in the cerebrospinal fluid and brain tissue. The level of immunoglobulins in the cerebrospinal fluid was found to be increased, however, their concentration did not exceed that in the blood serum which only indicates the possibility of their penetration through the hematoencephalic barrier. This factor, as well as the pattern of pathomorphological changes in the brain tissues indicate the toxicoallergic genesis of meningoencephalitis in acute respiratory diseases.
对96例流感及其他急性呼吸道病毒疾病患者的脑脊液和鼻咽冲洗液，以及14例有中枢神经系统受累症状患者的尸检材料进行病毒学检查，结果分离出呼吸道病毒，并在脑脊液和脑组织中检测到病毒抗原。发现脑脊液中免疫球蛋白水平升高，但其浓度未超过血清中的浓度，这仅表明它们有可能透过血脑屏障。这一因素以及脑组织病理形态学变化模式表明，急性呼吸道疾病中脑膜脑炎的发病机制为中毒性变态反应。
