Department of Developmental and Regenerative Biology, Institute of Molecular Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan.
Neuron. 2010 Jul 29;67(2):213-23. doi: 10.1016/j.neuron.2010.06.018.
In the long-range neuronal migration of adult mammals, young neurons travel from the subventricular zone to the olfactory bulb, a long journey (millimeters to centimeters, depending on the species). How can these neurons migrate through the dense meshwork of neuronal and glial processes of the adult brain parenchyma? Previous studies indicate that young neurons achieve this by migrating in chains through astrocytic tunnels. Here, we report that young migrating neurons actively control the formation and maintenance of their own migration route. New neurons secrete the diffusible protein Slit1, whose receptor, Robo, is expressed on astrocytes. We show that the Slit-Robo pathway is required for morphologic and organizational changes in astrocytes that result in the formation and maintenance of the astrocytic tunnels. Through this neuron-glia interaction, the new neurons regulate the formation of the astrocytic meshwork that is needed to enable their rapid and directional migration in adult brain.
在成年哺乳动物的长程神经元迁移中，年轻的神经元从侧脑室区迁移到嗅球，这是一段漫长的旅程（取决于物种，长度为数毫米至数厘米）。这些神经元如何能够穿过成年大脑实质中密集的神经元和神经胶质过程网络进行迁移？先前的研究表明，年轻的神经元通过沿着星形胶质细胞的隧道形成链状结构进行迁移。在这里，我们报告说，年轻的迁移神经元主动控制其自身迁移路径的形成和维持。新的神经元分泌可扩散的蛋白 Slit1，其受体 Robo 在星形胶质细胞上表达。我们表明 Slit-Robo 通路对于星形胶质细胞形态和组织学变化是必需的，这些变化导致星形胶质细胞隧道的形成和维持。通过这种神经元-胶质细胞相互作用，新的神经元调节星形胶质细胞网络的形成，这是使它们在成年大脑中快速和定向迁移所必需的。
