GATA 开关作为发育驱动因素。
GATA switches as developmental drivers.
机构信息
Division of Hematology/Oncology, Department of Pharmacology, Paul Carbone Comprehensive Cancer Center, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53705, USA.
出版信息
J Biol Chem. 2010 Oct 8;285(41):31087-93. doi: 10.1074/jbc.R110.159079. Epub 2010 Jul 29.
Abstract
Transcriptional networks orchestrate complex developmental processes. Such networks are commonly instigated by master regulators of development. Considerable progress has been made in elucidating GATA factor-dependent genetic networks that control blood cell development. GATA-2 is required for the genesis and/or function of hematopoietic stem cells, whereas GATA-1 drives the differentiation of hematopoietic progenitors into a subset of the blood cell lineages. GATA-1 directly represses Gata2 transcription, and this involves GATA-1-mediated displacement of GATA-2 from chromatin, a process termed a GATA switch. GATA switches occur at numerous loci with critical functions, indicating that they are widely utilized developmental control tools.
摘要
转录网络协调复杂的发育过程。此类网络通常由发育的主调控因子引发。在阐明控制血细胞发育的 GATA 因子依赖性遗传网络方面已经取得了相当大的进展。GATA-2 对于造血干细胞的发生和/或功能是必需的，而 GATA-1 则驱动造血祖细胞向血细胞谱系的一个子集分化。GATA-1 直接抑制 Gata2 的转录，这涉及 GATA-1 介导的 GATA-2 从染色质上的置换，这一过程称为 GATA 开关。GATA 开关发生在具有关键功能的许多基因座上，表明它们是广泛使用的发育控制工具。
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