van Ypersele de Strihou C, Jadoul M, Malghem J, Maldague B, Jamart J
University of Louvain, Medical School, Cliniques Universitaires St-Luc, Brussels, Belgium.
Kidney Int. 1991 May;39(5):1012-9. doi: 10.1038/ki.1991.128.
This 12 center study was designed to assess factors affecting the development and progression of beta 2-microglobulin amyloidosis in long-term dialysis. A total of 221 patients who were on hemodialysis for more than five years, and who were treated the entire time only with AN69, a biocompatible, highly permeable membrane, or cuprophane, a less permeable, poorly biocompatible membrane (Cell) were evaluated for time on dialysis, development of carpal tunnel syndrome, and cystic bone lesions. X-ray documentation was taken in a minimum of four of the six following joints: both hips, wrists and shoulders. The data demonstrate that patients treated solely by AN69 membranes display signs of bone amyloidosis less frequently than do those treated by Cell membranes. Age at onset of dialysis was found to have a striking correlation with the development of carpal tunnel syndrome and bone amyloidosis, while no significant influence was found for hyperparathyroidism, sex or year of first dialysis.
这项12中心研究旨在评估影响长期透析中β2-微球蛋白淀粉样变性发展和进展的因素。共有221名接受血液透析超过五年的患者接受了评估，这些患者在整个治疗期间仅使用生物相容性高、通透性强的AN69膜，或通透性较低、生物相容性较差的铜仿膜（Cell），评估指标包括透析时间、腕管综合征的发生情况以及囊性骨病变。对以下六个关节中的至少四个进行了X线记录：双髋、双腕和双肩。数据表明，仅接受AN69膜治疗的患者出现骨淀粉样变性体征的频率低于接受Cell膜治疗的患者。发现透析开始时的年龄与腕管综合征和骨淀粉样变性的发展有显著相关性，而甲状旁腺功能亢进、性别或首次透析年份未发现有显著影响。
