新型过渡金属配合物 6-甲基吡啶-2-甲醛-N(4)-乙基硫代缩氨基脲的抗肿瘤活性：[VO(2)(mpETSC)]和[Pt(mpETSC)Cl]的 X 射线晶体结构。

Department of Chemistry, McGill University, Montreal, QC, Canada H3A 2K6.

Bioinorg Chem Appl. 2010;2010:149149. doi: 10.1155/2010/149149. Epub 2010 Jul 1.

New complexes of dioxovanadium(V), zinc(II), ruthenium(II), palladium(II), and platinum(II) with 6-methylpyridine-2-carbaldehyde-N(4)-ethylthiosemicarbazone (HmpETSC) have been synthesized. The composition of these complexes is discussed on the basis of elemental analyses, IR, Raman, NMR ((1)H, (13)C, and (31)P), and electronic spectral data. The X-ray crystal structures of [VO(2)(mpETSC)] and [Pt(mpETSC)Cl] are also reported. The HmpETSC and its [Zn(HmpETSC)Cl(2)] and [Pd(mpETSC)Cl] complexes exhibit antineoplastic activity against colon cancer human cell lines (HCT 116).

已合成了一系列新的二氧钒(V)、锌(II)、钌(II)、钯(II)和铂(II)与 6-甲基吡啶-2-甲酰基-N(4)-乙基硫代半卡巴腙（HmpETSC）的配合物。根据元素分析、红外、拉曼、核磁共振（(1)H、(13)C 和 (31)P）和电子光谱数据讨论了这些配合物的组成。还报道了 [VO(2)(mpETSC)]和 [Pt(mpETSC)Cl] 的 X 射线晶体结构。HmpETSC 及其 [Zn(HmpETSC)Cl(2)] 和 [Pd(mpETSC)Cl] 配合物对结肠癌细胞系（HCT 116）表现出抗肿瘤活性。