van de Glind G J, Gidding C E M, Verlaat C M W, Duthoi K, Backx A P C, Verweij P E, Warris A
Department of Pediatrics, Radboud University Nijmegen Medical Centre, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands.
Case Rep Med. 2010;2010:241791. doi: 10.1155/2010/241791. Epub 2010 Jul 4.
Cardiac zygomycosis can be a critical condition with sudden onset of severe congestive heart failure followed by severe hemodynamic deterioration. We report a fatal course of disseminated fungal infection with a massive intra-atrial thrombosis caused by a zygomycete, in a five year old boy treated for acute lymphoblastic leukaemia. In addition, we discuss the literature concerning infections caused by zygomycetes involving the heart. Prognosis is poor. A high index of suspicion and an aggressive diagnostic and therapeutic approach with the prompt start of preemptive antifungal therapy are key factors to improve outcome.
心脏接合菌病可能是一种危急病症，可突然出现严重充血性心力衰竭，随后出现严重的血流动力学恶化。我们报告了一名五岁急性淋巴细胞白血病患儿因接合菌引起的播散性真菌感染伴大量心房内血栓形成的致死病例。此外，我们还讨论了有关接合菌引起的心脏感染的文献。预后很差。高度的怀疑指数以及积极的诊断和治疗方法，包括迅速开始先发制的抗真菌治疗，是改善预后的关键因素。
