一名急性淋巴细胞白血病患儿由柏氏小克银汉霉引起的肺接合菌病。
Pulmonary Zygomycosis caused by Cunninghamella bertholletiae in a child with acute lymphoblastic leukemia.
作者信息
Bibashi E, Sidi V, Kotsiou M, Makrigiannaki E, Koliouskas D
机构信息
Department of Microbiology, Hippokration General Hospital, Thessaloniki, Greece.
出版信息
Hippokratia. 2008 Jan;12(1):43-5.
Abstract
Zygomycosis is an invasive mycotic disease caused by fungi of the class Zygomycetes. Infections caused by zygomycetes, are known for their difficulty of diagnosis and treatment. Cunninghamella bertholletiae (Cb), is a saprobic fungus commonly found in the soil of temperate climates. Pulmonary infections caused by Cb are being identified with increasing frequency among patients on immunosuppressive therapy, and these infections usually have a fatal outcome. We present a rare case of pulmonary zygomycosis caused by Cb in a 10 year old male child with acute lymphoblastic leukemia. In spite of intensive antifungal chemotherapy (iv liposomal amphotericin B 7 mg/Kg once daily) following clinical diagnosis, he died of pulmonary failure.
摘要
接合菌病是一种由接合菌纲真菌引起的侵袭性霉菌病。由接合菌引起的感染以诊断和治疗困难而闻名。拜氏 Cunninghamella（Cb）是一种常见于温带气候土壤中的腐生真菌。在接受免疫抑制治疗的患者中，由 Cb 引起的肺部感染被发现的频率越来越高，而且这些感染通常会导致致命的后果。我们报告了一例罕见的由 Cb 引起的肺部接合菌病，患者为一名患有急性淋巴细胞白血病的 10 岁男童。尽管在临床诊断后进行了强化抗真菌化疗（静脉注射脂质体两性霉素 B，7 毫克/千克，每日一次），但他仍死于呼吸衰竭。
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本文引用的文献
1
Phycomycetous infection (mucormycosis) in cancer patients: a complication of therapy.
Cancer. 1959 Mar-Apr;12(2):330-50. doi: 10.1002/1097-0142(195903/04)12:2<330::aid-cncr2820120217>3.0.co;2-f.
2
Pulmonary mucormycosis: the last 30 years.肺毛霉病：过去30年
Arch Intern Med. 1999 Jun 28;159(12):1301-9. doi: 10.1001/archinte.159.12.1301.
3
Survival from pulmonary infection with Cunninghamella bertholletiae: case report and review of the literature.
Pediatr Infect Dis J. 1998 Sep;17(9):835-9. doi: 10.1097/00006454-199809000-00019.
4
Trends in the postmortem epidemiology of invasive fungal infections at a university hospital.某大学医院侵袭性真菌感染的尸检流行病学趋势
J Infect. 1996 Jul;33(1):23-32. doi: 10.1016/s0163-4453(96)92700-0.
5
Cunninghamella infections: review and report of two cases of Cunninghamella pneumonia in immunocompromised children.
Clin Infect Dis. 1993 Aug;17(2):173-7. doi: 10.1093/clinids/17.2.173.
6
Pulmonary mucormycosis: results of medical and surgical therapy.肺毛霉病：内科及外科治疗结果
Ann Thorac Surg. 1994 Apr;57(4):1044-50. doi: 10.1016/0003-4975(94)90243-7.
7
Studies with clinical isolates of Cunninghamella II. Physiological and morphological studies.康宁木霉临床分离株的研究II. 生理学和形态学研究
Mycologia. 1980 Jul-Aug;72(4):661-9.
8
Zygomycosis caused by Cunninghamella bertholletiae: clinical and pathologic aspects.拜氏伞霉引起的接合菌病：临床与病理方面
Arch Pathol Lab Med. 1982 Jun;106(6):282-6.
9
Fungal infections in cancer patients: an international autopsy survey.癌症患者的真菌感染：一项国际尸检调查。
Eur J Clin Microbiol Infect Dis. 1992 Feb;11(2):99-109. doi: 10.1007/BF01967060.
10
Studies with clinical isolates of Cunninghamella. I. Mating behavior.
Mycologia. 1979 Sep-Oct;71(5):1024-33.
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