Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia.
Pharm Biol. 2010 Aug;48(8):861-8. doi: 10.3109/13880200903302820.
Alpinia conchigera Griff. (Zingiberaceae), locally known to the Malays as "lengkuas ranting", is native to Peninsular Malaysia. The Malays traditionally used it to treat infection and rashes, and as a health drink. This study evaluated the analgesic and anti-inflammatory activities of the ethanol extract of A. conchigera rhizomes in mice and rats, respectively. The analgesic activity was elucidated using the acetic acid-induced writhing test, hot plate test, and formalin test, while the anti-inflammatory activity was determined using carrageenan-induced paw edema. The extract (30, 100, and 300 mg/kg) given intraperitoneally (i.p.) exhibited antinociceptive and anti-inflammatory activities in all tests used. The range of percentage of analgesia obtained for all doses of extract in the writhing test was 50-92%, and in the early and late phases of the formalin test was 25-62% and 63-98%, respectively. In addition, naloxone (5 mg/kg) given subcutaneously (s.c.) was found to reverse the extract (300 mg/kg)-induced antinociceptive activity in the writhing, hot plate, and formalin tests. Based on the results obtained, it can be concluded that the ethanol extract of A. conchigera rhizomes possessed a peripheral and central antinociceptive activity that was mediated, in part, via the opioid receptor, as well as anti-inflammatory activity.
益智（姜科），马来语称为“lengkuas ranting”，原产于马来西亚半岛。马来人传统上用它来治疗感染和皮疹，并作为健康饮料。本研究分别在小鼠和大鼠中评估了益智根茎乙醇提取物的镇痛和抗炎活性。使用醋酸诱导的扭体试验、热板试验和福氏完全佐剂诱导的炎症试验来阐明镇痛活性，而使用角叉菜胶诱导的足肿胀试验来确定抗炎活性。腹腔内给予提取物（30、100 和 300 mg/kg）在所有使用的试验中均表现出镇痛和抗炎活性。扭体试验中所有剂量提取物的镇痛百分比范围为 50-92%，在福氏完全佐剂诱导的炎症早期和晚期分别为 25-62%和 63-98%。此外，皮下给予纳洛酮（5 mg/kg）可逆转扭体、热板和福氏完全佐剂试验中提取物（300 mg/kg）诱导的镇痛活性。基于获得的结果，可以得出结论，益智根茎的乙醇提取物具有外周和中枢镇痛活性，部分通过阿片受体介导，并且具有抗炎活性。
