Pis'ko G T, Dombrovskiĭ A P
Mikrobiol Zh (1978). 1991 Jan-Feb;53(1):82-4.
The paper deals with the experimental study of antistaphylococcal properties of thionium--a derivative of bis-quarternary ammonium compounds. High bactericide activity of the preparation is revealed as a result; it is preserved under high contents of protein substances in the media. The sensitivity of staphylococcal strains to thionium is not affected by the initial sensitivity of microorganisms to antibiotics. The preparations interaction with benzylpenicillin and gentamycin has been studied. Synergist effect of sub-bacteriostatic doses of thionium with the mentioned antibiotics has been found. Effect of benzylpenicillin increases 4-32 times, that of gentamycin--64-512 times independent of the primary sensitivity to these antibiotics. The further study of a new antistaphylococcal preparation is advisable.
本文论述了硫鎓（双季铵化合物的衍生物）抗葡萄球菌特性的实验研究。结果表明该制剂具有高杀菌活性；在培养基中蛋白质物质含量高的情况下仍能保持。葡萄球菌菌株对硫鎓的敏感性不受微生物对抗生素初始敏感性的影响。研究了该制剂与苄青霉素和庆大霉素的相互作用。发现硫鎓亚抑菌剂量与上述抗生素具有协同作用。苄青霉素的效果提高了4 - 32倍，庆大霉素的效果提高了64 - 512倍，且与对这些抗生素的初始敏感性无关。进一步研究这种新型抗葡萄球菌制剂是可取的。
