Gudz' O V, Pis'ko G T
Antibiotiki. 1982;27(9):672-4.
The inhibitory effect of antibiotics and their combinations with ethonium was studied in vitro with 10 strains of Staph. aureus and 10 strains of E. coli, Sh. sonnei and Pr. morganii. Ethonium is an antimicrobial drug of the group of cationic surface-active substances. The study was performed with the method of serial dilutions in a liquid nutrient medium. It was found that under the effect of the subbacteriostatic concentrations of ethonium, sensitivity of the microorganisms to benzylpenicillin, streptomycin, levomycetin and tetracycline increased 4-16, 2-8, 2-32 and 64-256 times, respectively. Along with the increasing of the antibiotic activity, ethonium promoted a decrease in the rate of the Staph. aureus adaptation to the above antibiotics.
采用10株金黄色葡萄球菌以及10株大肠杆菌、宋内志贺菌和摩根氏变形杆菌，在体外研究了抗生素及其与乙铵组合的抑制作用。乙铵是阳离子表面活性物质类抗菌药物。研究在液体营养培养基中采用系列稀释法进行。结果发现，在低于抑菌浓度的乙铵作用下，微生物对苄青霉素、链霉素、氯霉素和四环素的敏感性分别提高了4至16倍、2至8倍、2至32倍和64至256倍。随着抗生素活性的增强，乙铵促使金黄色葡萄球菌对上述抗生素的适应率降低。
