Division of Cardiothoracic Surgery, Department of Surgery, University of Minnesota, Minneapolis, Minnesota 55455, USA.
J Heart Lung Transplant. 2010 Dec;29(12):1321-9. doi: 10.1016/j.healun.2010.06.006. Epub 2010 Jul 31.
The increased applicability and excellent results with left ventricular assist devices (LVADs) have revolutionized the available treatment options for patients with advanced heart failure. Pre-existing valve abnormalities are common in this population, and subsequent development of valve abnormalities after LVAD placement is also often noted. Although native mitral and tricuspid valve disease is more common in heart failure patients before LVAD placement, aortic valves are much more likely to generate abnormal pathophysiology in the LVAD patient during as well as after LVAD placement. The aim of this comprehensive review is to review aortic valve function in LVAD patients and highlight the consideration of pre-existing valve disease on patient treatment at the time of LVAD implant. The basis for structural changes leading to valve pathophysiology during and after LVAD placement will be described, providing a basis for improved clinical understanding and new strategies to prevent these conditions.
左心室辅助装置（LVAD）的应用日益广泛，效果极佳，为晚期心力衰竭患者的治疗提供了新的选择。该人群中常存在先前存在的瓣膜异常，LVAD 植入后瓣膜异常的后续发展也经常被注意到。虽然在 LVAD 植入前，心力衰竭患者中更常见的是二尖瓣和三尖瓣的原生疾病，但在 LVAD 患者中，主动脉瓣在 LVAD 植入期间和之后更有可能产生异常的病理生理学改变。本综述的目的是回顾 LVAD 患者的主动脉瓣功能，并强调在 LVAD 植入时考虑患者的先前存在的瓣膜疾病。将描述导致 LVAD 植入期间和之后瓣膜病理生理学改变的结构变化的基础，为改善临床认识和预防这些疾病的新策略提供依据。
