Department of Urology, Guy's and St Thomas' NHS Foundation Trust, London, UK.
Urol Clin North Am. 2010 Aug;37(3):421-34. doi: 10.1016/j.ucl.2010.04.005.
Patients with penile cancer who are proven to have negative inguinal lymph nodes have an excellent prognosis. Furthermore, patients with small-volume inguinal node involvement can often be cured by surgery alone. Lymphadenectomy has clear survival benefits for patients when applied to those with lymph node metastasis. However, the current morbidity of the standard technique of lymphadenectomy is an impediment to its universal application, and innovative strategies to reduce the morbidity of staging/treatment that do not compromise oncologic control must be developed and standardized. The optimal integration of multimodality therapy to improve survival in advanced disease will occur only through collaborative studies between centers with significant patient volume, which would be facilitated through the development of regional referral centers.
患有阴茎癌且腹股沟淋巴结阴性的患者预后极佳。此外，对于腹股沟淋巴结受累量较小的患者，单独手术通常即可治愈。当淋巴结转移患者接受淋巴结清扫术时，该手术具有明确的生存获益。然而，目前标准淋巴结清扫术的发病率阻碍了其广泛应用，必须开发和标准化创新性策略，以降低分期/治疗的发病率，同时不影响肿瘤控制。只有通过具有大量患者的中心之间的合作研究，才能实现通过多模式治疗改善晚期疾病的生存，而区域性转诊中心的发展将有助于实现这一目标。
