Department of Epidemiology and Clinical Microbiology, National Reference Centre for Bacterial Meningitis, National Medicines Institute, Warsaw, Poland.
Vaccine. 2010 Sep 7;28(39):6406-7. doi: 10.1016/j.vaccine.2010.07.051. Epub 2010 Jul 30.
We report the first invasive Streptococcus pneumoniae isolates of serotype 6D and the first occurrence of this serotype in Europe. Till now, the appearance of serotype 6D pneumococci in nasopharyngeal carriage has been speculated to be associated with a selective pressure from vaccination with the conjugated 7-valent antipneumococcal vaccine. Our observations indicate that this serotype is present also among unvaccinated individuals in the population where mass infant vaccination has not yet been introduced. Importantly, these strains were isolated from invasive infections, indicating the full virulence potential of pneumococci belonging to serotype 6D and its importance for future vaccine formulations.
我们报告了欧洲首例侵袭性 6D 型肺炎链球菌分离株，也是该血清型首次在欧洲出现。到目前为止，推测 7 价结合型肺炎球菌疫苗接种带来的选择压力与鼻咽携带 6D 型肺炎球菌之间存在关联。我们的观察结果表明，在尚未大规模开展婴儿疫苗接种的人群中，未接种疫苗的个体中也存在该血清型。重要的是，这些菌株是从侵袭性感染中分离出来的，表明属于 6D 型的肺炎球菌具有完全的毒力潜力，这对未来的疫苗配方非常重要。
