• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Multidrug-resistant Streptococcus pneumoniae serotype 6D clones in South Korea.韩国多重耐药性肺炎链球菌 6D 血清型克隆。
J Clin Microbiol. 2012 Mar;50(3):818-22. doi: 10.1128/JCM.05895-11. Epub 2011 Dec 14.
2
Clinical and microbiological characterization of serotype 6D pneumococcal infections in South Korea.韩国6D型肺炎球菌感染的临床和微生物学特征
J Infect Chemother. 2016 Aug;22(8):515-20. doi: 10.1016/j.jiac.2016.04.005. Epub 2016 May 24.
3
Comparison of capsular genes of Streptococcus pneumoniae serotype 6A, 6B, 6C, and 6D isolates.6A、6B、6C 和 6D 型肺炎链球菌分离株荚膜基因的比较。
J Clin Microbiol. 2011 May;49(5):1758-64. doi: 10.1128/JCM.02628-10. Epub 2011 Mar 16.
4
Comparison of genotypes of Streptococcus pneumoniae serotypes 6A and 6B before and after the introduction of PCV7 vaccination in Korea.比较韩国引入 PCV7 疫苗前后肺炎链球菌血清型 6A 和 6B 的基因型。
Diagn Microbiol Infect Dis. 2011 Apr;69(4):370-5. doi: 10.1016/j.diagmicrobio.2010.10.019.
5
Capsular polysaccharide gene diversity of pneumococcal serotypes 6A, 6B, 6C, and 6D.肺炎球菌6A、6B、6C和6D血清型的荚膜多糖基因多样性
Int J Med Microbiol. 2014 Nov;304(8):1109-17. doi: 10.1016/j.ijmm.2014.08.004. Epub 2014 Aug 17.
6
Frequency and molecular characterization of invasive isolates of Streptococcus pneumoniae serotypes 6C and 6D in Colombia.哥伦比亚肺炎链球菌6C和6D血清型侵袭性分离株的频率及分子特征
Enferm Infecc Microbiol Clin. 2017 May;35(5):283-286. doi: 10.1016/j.eimc.2016.01.014. Epub 2016 Mar 11.
7
Prevalence of isolates of Streptococcus pneumoniae putative serotype 6E in South Korea.韩国肺炎链球菌假定血清型6E分离株的流行情况。
J Clin Microbiol. 2014 Jun;52(6):2096-9. doi: 10.1128/JCM.00228-14. Epub 2014 Apr 9.
8
Emergence of a multidrug-resistant clone (ST320) among invasive serotype 19A pneumococci in Spain.西班牙侵袭性19A血清型肺炎球菌中出现多重耐药克隆（ST320）
J Antimicrob Chemother. 2009 Sep;64(3):507-10. doi: 10.1093/jac/dkp210. Epub 2009 Jun 17.
9
Relationship between the original multiply resistant South African isolates of Streptococcus pneumoniae from 1977 to 1978 and contemporary international resistant clones.1977年至1978年南非肺炎链球菌原始多重耐药菌株与当代国际耐药克隆之间的关系。
J Clin Microbiol. 2005 Dec;43(12):6035-41. doi: 10.1128/JCM.43.12.6035-6041.2005.
10
Population snapshot of emergent Streptococcus pneumoniae serotype 19A in the United States, 2005.2005年美国新出现的肺炎链球菌19A血清型的人群概况
J Infect Dis. 2008 Apr 1;197(7):1016-27. doi: 10.1086/528996.

引用本文的文献

1
Effects of Pneumococcal Conjugate Vaccine on Genotypic Penicillin Resistance and Serotype Changes, Japan, 2010-2017.2010-2017 年日本肺炎球菌结合疫苗对青霉素基因型耐药性和血清型变化的影响。
Emerg Infect Dis. 2018 Nov;24(11):2010-2020. doi: 10.3201/eid2411.180326.
2
Serotype 6B from a pneumococcal polysaccharide vaccine induces cross-functional antibody responses in adults to serotypes 6A, 6C, and 6D.来自肺炎球菌多糖疫苗的6B血清型可诱导成年人对6A、6C和6D血清型产生交叉功能抗体反应。
Medicine (Baltimore). 2016 Sep;95(37):e4854. doi: 10.1097/MD.0000000000004854.
3
Serotype Changes and Drug Resistance in Invasive Pneumococcal Diseases in Adults after Vaccinations in Children, Japan, 2010-2013.2010 - 2013年日本儿童接种疫苗后成人侵袭性肺炎球菌疾病的血清型变化及耐药性
Emerg Infect Dis. 2015 Nov;21(11):1956-65. doi: 10.3201/eid2111.142029.
4
Serotype distribution and antibiotic resistance of Streptococcus pneumoniae isolates collected at a Chinese hospital from 2011 to 2013.2011年至2013年在中国一家医院收集的肺炎链球菌分离株的血清型分布及抗生素耐药性
BMC Infect Dis. 2015 Aug 5;15:312. doi: 10.1186/s12879-015-1042-5.
5
The relevance of pneumococcal serotypes.肺炎球菌血清型的相关性。
Curr Infect Dis Rep. 2014 Apr;16(4):403. doi: 10.1007/s11908-014-0403-3.
6
Nasopharyngeal Carriage Rate and Serotypes of Streptococcus pneumoniae and Antimicrobial Susceptibility in Healthy Korean Children Younger than 5 Years Old: Focus on Influence of Pneumococcal Conjugate Vaccination.5岁以下健康韩国儿童肺炎链球菌的鼻咽携带率、血清型及抗菌药物敏感性：聚焦肺炎球菌结合疫苗的影响
Infect Chemother. 2013 Mar;45(1):76-84. doi: 10.3947/ic.2013.45.1.76. Epub 2013 Mar 29.
7
The 7-valent pneumococcal conjugate vaccine elicits cross-functional opsonophagocytic killing responses to Streptococcus pneumoniae serotype 6D in children.7价肺炎球菌结合疫苗可引发儿童对肺炎链球菌6D血清型的交叉功能性调理吞噬杀伤反应。
BMC Infect Dis. 2013 Oct 10;13:474. doi: 10.1186/1471-2334-13-474.
8
Capsular gene sequences and genotypes of "serotype 6E" Streptococcus pneumoniae isolates.荚膜基因序列和“血清型 6E”肺炎链球菌分离株的基因型。
J Clin Microbiol. 2013 Oct;51(10):3395-9. doi: 10.1128/JCM.01645-13. Epub 2013 Jul 3.
9
Baseline epidemiology and genetic structure of Streptococcus pneumoniae serotype 6D in southern Israel prior to introduction of pneumococcal conjugate vaccines.在肺炎球菌结合疫苗引入之前，以色列南部 6D 型肺炎链球菌的基线流行病学和遗传结构。
J Clin Microbiol. 2013 May;51(5):1580-2. doi: 10.1128/JCM.03320-12. Epub 2013 Feb 27.
10
Clinical implications of pneumococcal serotypes: invasive disease potential, clinical presentations, and antibiotic resistance.肺炎链球菌血清型的临床意义：侵袭性疾病潜能、临床表现和抗生素耐药性。
J Korean Med Sci. 2013 Jan;28(1):4-15. doi: 10.3346/jkms.2013.28.1.4. Epub 2013 Jan 8.

本文引用的文献

1
Type distribution of serogroup 6 Streptococcus pneumoniae and molecular epidemiology of newly identified serotypes 6C and 6D in China.中国 6 群肺炎链球菌血清型分布及新发现血清型 6C 和 6D 的分子流行病学研究。
Diagn Microbiol Infect Dis. 2011 Jul;70(3):291-8. doi: 10.1016/j.diagmicrobio.2011.03.015. Epub 2011 May 4.
2
First report of Streptococcus pneumoniae serotype 6D in South America.南美洲肺炎链球菌6D血清型的首次报告。
J Clin Microbiol. 2011 May;49(5):2080-1. doi: 10.1128/JCM.00153-11. Epub 2011 Mar 23.
3
Comparison of capsular genes of Streptococcus pneumoniae serotype 6A, 6B, 6C, and 6D isolates.6A、6B、6C 和 6D 型肺炎链球菌分离株荚膜基因的比较。
J Clin Microbiol. 2011 May;49(5):1758-64. doi: 10.1128/JCM.02628-10. Epub 2011 Mar 16.
4
Comparison of genotypes of Streptococcus pneumoniae serotypes 6A and 6B before and after the introduction of PCV7 vaccination in Korea.比较韩国引入 PCV7 疫苗前后肺炎链球菌血清型 6A 和 6B 的基因型。
Diagn Microbiol Infect Dis. 2011 Apr;69(4):370-5. doi: 10.1016/j.diagmicrobio.2010.10.019.
5
Rapid pneumococcal evolution in response to clinical interventions.临床干预措施下肺炎链球菌的快速进化。
Science. 2011 Jan 28;331(6016):430-4. doi: 10.1126/science.1198545.
6
Streptococcus pneumoniae serotype 6D cross-reacting with serotype 6A, 6B, and 6C factor sera.肺炎链球菌6D血清型与6A、6B和6C因子血清发生交叉反应。
J Clin Microbiol. 2011 Feb;49(2):765-6. doi: 10.1128/JCM.01933-10. Epub 2010 Dec 1.
7
Prevalence and genetic structures of Streptococcus pneumoniae serotype 6D, South Korea.韩国肺炎链球菌 6D 血清型的流行情况及遗传结构。
Emerg Infect Dis. 2010 Nov;16(11):1751-3. doi: 10.3201/eid1611.100941.
8
Evolution of the capsular gene locus of Streptococcus pneumoniae serogroup 6.肺炎链球菌 6 血清型荚膜基因座的进化。
Microbiology (Reading). 2011 Jan;157(Pt 1):189-198. doi: 10.1099/mic.0.043901-0. Epub 2010 Oct 7.
9
The prevalence and characteristics of Streptococcus pneumoniae isolates expressing serotypes 6C and 6D in Hong Kong prior to the introduction of the 7-valent pneumococcal conjugate vaccine.在 7 价肺炎球菌结合疫苗引入香港之前，表达血清型 6C 和 6D 的肺炎链球菌分离株的流行情况和特征。
Diagn Microbiol Infect Dis. 2010 Dec;68(4):439-44. doi: 10.1016/j.diagmicrobio.2010.07.020.
10
Isolation of Streptococcus pneumoniae serotypes 6C and 6D from the nasopharyngeal mucosa of healthy Japanese children.
Jpn J Infect Dis. 2010 Sep;63(5):381-3.

韩国多重耐药性肺炎链球菌 6D 血清型克隆。

Multidrug-resistant Streptococcus pneumoniae serotype 6D clones in South Korea.

机构信息

Department of Molecular Cell Biology, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Suwon, South Korea.

出版信息

J Clin Microbiol. 2012 Mar;50(3):818-22. doi: 10.1128/JCM.05895-11. Epub 2011 Dec 14.

DOI:10.1128/JCM.05895-11
PMID:22170935
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3295089/
Abstract

To investigate the characteristics of main Streptococcus pneumoniae clones of serotype 6D (ST282 and ST3171) in South Korea, antimicrobial susceptibility testing was performed, and 11 genes around the cps locus were sequenced on ST282(6D), ST3171(6D), and ST81(6A) isolates. The antimicrobial susceptibility patterns were very similar between clones belonging to the same clonal complex, ST81(6A) and ST282(6D); nonsusceptibilities to penicillin and cefuroxime, high MICs of ceftriaxone, and high resistance rates to trimethoprim-sulfamethoxazole. However, ST3171(6D) isolates showed resistance to only macrolides and clindamycin. The sequences of 11 genes around the cps locus indicated the same genetic backgrounds between the ST81(6A) and ST282(6D) isolates. On the other hand, ST3171(6D) isolates showed nucleotide and amino acid differences from ST81(6A) and ST282(6D) isolates in most genes, indicating a different genetic background. The mosaic structure of dexB gene in ST282(6D) isolates indicated that recombination might occur in the dexB gene. Our results suggest that the multidrug-resistant ST282(6D) pneumococcal clone has emerged by serial genetic recombination, including capsular switch.

摘要

为了研究韩国血清型 6D（ST282 和 ST3171）主要肺炎链球菌克隆的特征，对其进行了抗生素敏感性测试，并对 ST282（6D）、ST3171（6D）和 ST81（6A）分离株的 cps 基因座周围的 11 个基因进行了测序。属于同一克隆复合体的克隆，如 ST81（6A）和 ST282（6D），其抗生素敏感性模式非常相似；对青霉素和头孢呋辛的不敏感性、头孢曲松的高 MIC 值以及对复方磺胺甲噁唑的高耐药率。然而，ST3171（6D）分离株仅对大环内酯类和克林霉素表现出耐药性。cps 基因座周围 11 个基因的序列表明 ST81（6A）和 ST282（6D）分离株具有相同的遗传背景。另一方面，ST3171（6D）分离株在大多数基因中与 ST81（6A）和 ST282（6D）分离株表现出核苷酸和氨基酸差异，表明其具有不同的遗传背景。ST282（6D）分离株的 dexB 基因的镶嵌结构表明该基因可能发生了重组。我们的研究结果表明，多药耐药的 ST282（6D）肺炎链球菌克隆通过包括荚膜转换在内的连续基因重组而出现。