Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada.
J Pediatr. 2010 Dec;157(6):989-994.e1. doi: 10.1016/j.jpeds.2010.06.016. Epub 2010 Aug 3.
To evaluate the mortality and long-term morbidity rates of extremely low birth weight (ELBW) infants admitted to neonatal intensive care units (NICUs).
This was a longitudinal cohort study of all admissions born between 1983 and 2003 with birth weight ≤ 800 g at a single tertiary NICU. Trends in survival and neurodevelopmental outcome rates at school entry in four 5-year epochs were analyzed.
Of 917 admissions, 552 survived to NICU discharge, with significantly increasing survival rates from 46% in epoch 1 to 71% in epoch 4 (P < .0001). Although the overall impairment rate of 30% did not change, the pattern of impairments did. Cognitive (P = .017) and hearing (P = .014) impairment rates increased. Visual impairment rates decreased (P = .042), with a trend toward decreasing cerebral palsy from 20% to 12% (P = .061).
Improved survival of low birth weight preterm infants has been associated with different types of neurodevelopmental impairments, including increased cognitive impairment rates.
评估入住新生儿重症监护病房（NICU）的极低出生体重（ELBW）婴儿的死亡率和长期发病率。
这是一项对单一生后护理中心（NICU）在 1983 年至 2003 年间出生、体重≤800 克的所有婴儿进行的纵向队列研究。分析了在四个 5 年时期中，入学时的存活率和神经发育结局率的趋势。
在 917 例入院婴儿中，有 552 例在 NICU 出院时存活，存活率从第 1 时期的 46%显著增加到第 4 时期的 71%（P<.0001）。尽管整体损伤率为 30%没有变化，但损伤模式发生了变化。认知（P=0.017）和听力（P=0.014）损伤率增加。视力损伤率下降（P=0.042），脑瘫的发生率从 20%下降到 12%（P=0.061）。
低出生体重早产儿存活率的提高与不同类型的神经发育损伤有关，包括认知损伤率的增加。
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