脑啡肽和P物质对小鼠输精管交感神经传递的影响。

Effect of enkephalin and substance P on sympathetic nerve transmission in mouse vas deferens.

作者信息

Segawa T, Murakami H, Ogawa H, Yajima H

出版信息

Jpn J Pharmacol. 1978 Feb;28(1):13-9. doi: 10.1254/jjp.28.13.

DOI:10.1254/jjp.28.13

PMID:206750

Abstract

Effect of methionine-, leucine-enkephalin (met-, leu-enkephalin) and substance P on the transmission in mouse vas deferens was studied. Both met- and leu-enkephalin inhibited electrically induced contraction of vas deferens at 10(-8)-10(7) M, met-enkephalin being 1.4 times more active than leu-enkephalin. Nalorphine (10(-6) M) antagonized these effects. Substance P (10(-9)-10(-7) M) had no effect on the contraction. Met- and leu-enkephalin (10(-7)-10(-5) M) decreased the high potassium induced [3H]-norepinephrine release from vas deferens, while substance P (10(-6) M) significantly increased it. Nalorphine (10(-5) M) reversed the inhibitory effect of met-enkephalin. These results indicate that these peptides modify the transmission of sympathetic nerve in mouse vas deferens.

摘要

研究了蛋氨酸脑啡肽、亮氨酸脑啡肽（甲硫-、亮-脑啡肽）和P物质对小鼠输精管传递的影响。甲硫-和亮-脑啡肽在10^(-8) - 10^(7) M浓度下均抑制输精管的电诱导收缩，甲硫-脑啡肽的活性比亮-脑啡肽高1.4倍。烯丙吗啡（10^(-6) M）拮抗这些作用。P物质（10^(-9) - 10^(-7) M）对收缩无影响。甲硫-和亮-脑啡肽（10^(-7) - 10^(-5) M）减少了高钾诱导的输精管[3H]-去甲肾上腺素释放，而P物质（10^(-6) M）则显著增加了该释放。烯丙吗啡（10^(-5) M）逆转了甲硫-脑啡肽的抑制作用。这些结果表明，这些肽可调节小鼠输精管中交感神经的传递。