电流强度对小鼠输精管对甲硫氨酸脑啡肽和亮氨酸脑啡肽抑制反应的不同影响。
Different effects of current strength on inhibitory responses of the mouse vas deferens to methionine- and leucine-enkephalin.
作者信息
Hart S L, Kitchen I, Waddell P R
出版信息
Br J Pharmacol. 1979 Jul;66(3):361-3. doi: 10.1111/j.1476-5381.1979.tb10838.x.
Abstract
The inhibitory potency of methionine (Met)-enkephalin on the field-stimulated mouse vas deferens was greatly increased by a reduction in current strength whilst that of leucine (Leu)-enkephalin increased only slightly. All currents were submaximal and all muscle twitches were neuronally evoked. These results suggest that inhibitory effects of Met- and Leu-enkephalin in the mouse vas deferens are not commonly mediated and provide a rapid method for ascertaining heterogeneity of enkephalin extracts.
摘要
通过降低电流强度，甲硫氨酸（Met）-脑啡肽对电场刺激的小鼠输精管的抑制效力显著增强，而亮氨酸（Leu）-脑啡肽的抑制效力仅略有增加。所有电流均为次最大电流，所有肌肉抽搐均由神经元诱发。这些结果表明，Met-脑啡肽和Leu-脑啡肽在小鼠输精管中的抑制作用并非通过共同机制介导，并且提供了一种确定脑啡肽提取物异质性的快速方法。
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