大鼠输精管：一种用于内源性阿片肽的特异性生物测定法。
Rat vas deferens: a specific bioassay for endogenous opioid peptides.
作者信息
Lemaire S, Magnan J, Regoli D
出版信息
Br J Pharmacol. 1978 Nov;64(3):327-9. doi: 10.1111/j.1476-5381.1978.tb08653.x.
Abstract
The electrically-evoked contractions of the rat vas deferens were selectively inhibited by beta-endorphin, the preparation being much less sensitive to enkephalins and narcotic analgesic drugs. However, introduction of D-Ala in position 2 of [Leu]-enkephalin enhanced the activity of the opioid peptide to the order of that of beta-endorphin. It is concluded that the rat vas deferens preparation constitutes a specific bioassay for endogenous opioid peptides and related compounds.
摘要
β-内啡肽可选择性抑制大鼠输精管的电诱发收缩，该制剂对脑啡肽和麻醉性镇痛药的敏感性要低得多。然而，在[亮氨酸]-脑啡肽的第2位引入D-丙氨酸可增强阿片肽的活性，使其达到β-内啡肽的活性水平。结论是，大鼠输精管制剂构成了一种用于内源性阿片肽及相关化合物的特异性生物测定法。
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本文引用的文献
1
A new example of a morphine-sensitive neuro-effector junction: adrenergic transmission in the mouse vas deferens.吗啡敏感型神经效应器连接的一个新实例：小鼠输精管中的肾上腺素能传递。
Br J Pharmacol. 1972 Dec;46(4):764-6. doi: 10.1111/j.1476-5381.1972.tb06901.x.
2
Identification of two related pentapeptides from the brain with potent opiate agonist activity.从大脑中鉴定出两种具有强效阿片激动剂活性的相关五肽。
Nature. 1975 Dec 18;258(5536):577-80. doi: 10.1038/258577a0.
3
Opioid activity of a peptide, beta-lipotropin-(61-91), derived from beta-lipotropin.源自β-促脂素的一种肽β-促脂素-（61-91）的阿片样活性。
Proc Natl Acad Sci U S A. 1976 Jun;73(6):1821-3. doi: 10.1073/pnas.73.6.1821.
4
(D-Ala2)-Met-enkephalinamide: a potent, long-lasting synthetic pentapeptide analgesic.（D-丙氨酸2）-甲硫氨酸脑啡肽酰胺：一种强效、长效的合成五肽镇痛药。
Science. 1976 Oct 15;194(4262):330-2. doi: 10.1126/science.968485.
5
The synthesis and opiate activity of beta-endorphin.β-内啡肽的合成与阿片活性。
Biochem Biophys Res Commun. 1976 Jul 12;71(1):19-25. doi: 10.1016/0006-291x(76)90243-6.
6
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J Pharmacol Exp Ther. 1976 Jun;197(3):517-32.
7
[Endorphins, hypothalamic and neurohypophysial peptides with morphinomimetic activity: isolation and molecular structure of alpha-endorphin].
C R Acad Hebd Seances Acad Sci D. 1976 Feb 23;282(8):783-5.
8
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Br J Pharmacol. 1975 Mar;53(3):371-81. doi: 10.1111/j.1476-5381.1975.tb07373.x.
9
Endogenous opioid peptides: multiple agonists and receptors.内源性阿片肽：多种激动剂和受体。
Nature. 1977 Jun 9;267(5611):495-9. doi: 10.1038/267495a0.
10
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