Lemaire S, Magnan J, Regoli D
Br J Pharmacol. 1978 Nov;64(3):327-9. doi: 10.1111/j.1476-5381.1978.tb08653.x.
The electrically-evoked contractions of the rat vas deferens were selectively inhibited by beta-endorphin, the preparation being much less sensitive to enkephalins and narcotic analgesic drugs. However, introduction of D-Ala in position 2 of [Leu]-enkephalin enhanced the activity of the opioid peptide to the order of that of beta-endorphin. It is concluded that the rat vas deferens preparation constitutes a specific bioassay for endogenous opioid peptides and related compounds.
β-内啡肽可选择性抑制大鼠输精管的电诱发收缩，该制剂对脑啡肽和麻醉性镇痛药的敏感性要低得多。然而，在[亮氨酸]-脑啡肽的第2位引入D-丙氨酸可增强阿片肽的活性，使其达到β-内啡肽的活性水平。结论是，大鼠输精管制剂构成了一种用于内源性阿片肽及相关化合物的特异性生物测定法。
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