Lomonosov Moscow State University, Chemistry Department, Analytical Chemistry Division, Leninskie Gory, d.1, str.3, 119991 Moscow, Russian Federation.
J Pharm Biomed Anal. 2010 Dec 15;53(5):1170-9. doi: 10.1016/j.jpba.2010.07.005. Epub 2010 Jul 13.
The review summarizes the use of the chiral capillary electrophoresis (CE) with different class of antibiotics as chiral selectors in the pharmaceutical field. Basic factors influencing the enantioseparation are shortly discussed. Non-aqueous capillary electrophoresis is also included as well as the coupling of CE to MS. The selection of a chiral selector according the ionic state and structure of the analyte is described. Summary of pharmaceutical applications of chiral CE is given.
本文综述了手性毛细管电泳（CE）在药学领域中不同类型抗生素作为手性选择剂的应用。简要讨论了影响对映体分离的基本因素。还包括非水毛细管电泳以及 CE 与 MS 的耦合。根据分析物的离子状态和结构选择手性选择剂的方法也有所描述。给出了手性 CE 在药物方面应用的总结。
