日本不规则红细胞抗体的协作研究：亚洲人群同种免疫与抗原多样性日本研究小组的结果

Collaborative study of irregular erythrocyte antibodies in Japan: results from the Japanese study group of allo-immunity and antigen diversity in Asian populations.

作者信息

Takeshita Akihiro, Watanabe Hiroko, Fijihara Harumi, Oshida Machiko, Yurugi Kimiko, Tomoda Yutaka, Uchikawa Makoto, Kino Shuichi, Ohto Hitoshi

机构信息

Transfusion and Cell Therapy, Hamamatsu University School of Medicine, 1-20-1 Handayama, Naka-ku, Hamamatsu 431-3192, Japan.

出版信息

Transfus Apher Sci. 2010 Aug;43(1):3-8. doi: 10.1016/j.transci.2010.04.001. Epub 2010 Aug 2.

DOI:10.1016/j.transci.2010.04.001

PMID:20675192

Abstract

As a national study, we evaluated the frequencies of irregular erythrocyte antibodies (Abs) by gender and history of transfusion or pregnancy. In total, data from 248,785 patients were analyzed, from whom 4222 irregular erythrocyte Abs were detected in 3554 cases (1.43%). Abs frequencies in these 4222 cases were as follows: anti-E, 26%; anti-Le(a), 26%; anti-P(1), 11%; anti-M, 6%; anti-E+c, 4%; anti-Fy(b), 4%; anti-Di(a), 3%; anti-Le(b), 3%; and anti-D, 2%. In pregnancy, anti-D (5%), anti-Jr(a) (3%) and anti-E+c (6%) Abs were, with statistical significance, more frequent. Among transfused patients, anti-E (38%), anti-E+c (8%), anti-Jk(a) (4%), anti-e+C (2%) and anti-E+Jk(a) (1%) Abs were, with statistical significance, more frequent.

摘要

作为一项全国性研究，我们按性别以及输血或妊娠史评估了不规则红细胞抗体（Abs）的频率。总共分析了来自248,785名患者的数据，其中在3554例（1.43%）中检测到4222种不规则红细胞抗体。这4222例中的抗体频率如下：抗-E，26%；抗-Le(a)，26%；抗-P(1)，11%；抗-M，6%；抗-E+c，4%；抗-Fy(b)，4%；抗-Di(a)，3%；抗-Le(b)，3%；以及抗-D，2%。在妊娠患者中，抗-D（5%）、抗-Jr(a)（3%）和抗-E+c（6%）抗体在统计学上更为常见。在输血患者中，抗-E（38%）、抗-E+c（8%）、抗-Jk(a)（4%）、抗-e+C（2%）和抗-E+Jk(a)（1%）抗体在统计学上更为常见。