Koziol J A
Department of Molecular and Experimental Medicine, Scripps Clinic and Research Foundation, La Jolla, CA 92037.
Mutat Res. 1991 Jul;249(1):275-80. doi: 10.1016/0027-5107(91)90154-g.
The maximum likelihood and Luria-Delbrück P0 methods for the estimation of spontaneous mutation rates are compared. The maximum likelihood method is fully efficient, utilizing all available information in a fluctuation experiment, but can be numerically cumbersome. Under certain conditions, there is little loss of efficiency using the P0 method, which is readily implemented numerically. Design considerations should aid investigators in minimizing statistical errors associated with the statistical analysis of fluctuation experiments.
对用于估计自发突变率的最大似然法和鲁里亚-德尔布吕克P0法进行了比较。最大似然法是完全有效的，它利用了波动实验中的所有可用信息，但在数值计算上可能很繁琐。在某些条件下，使用P0法效率损失很小，且该方法在数值计算上易于实现。设计考量应有助于研究人员将与波动实验统计分析相关的统计误差降至最低。
