一种用于调节代谢的 NAC：来自肺炎克雷伯氏菌的氮同化控制蛋白（NAC）。
A NAC for regulating metabolism: the nitrogen assimilation control protein (NAC) from Klebsiella pneumoniae.
机构信息
Department of Molecular, Cellular, and Developmental Biology, the University of Michigan, Ann Arbor, MI 48109-1048, USA.
出版信息
J Bacteriol. 2010 Oct;192(19):4801-11. doi: 10.1128/JB.00266-10. Epub 2010 Jul 30.
Abstract
The nitrogen assimilation control protein (NAC) is a LysR-type transcriptional regulator (LTTR) that is made under conditions of nitrogen-limited growth. NAC's synthesis is entirely dependent on phosphorylated NtrC from the two-component Ntr system and requires the unusual sigma factor σ54 for transcription of the nac gene. NAC activates the transcription of σ70-dependent genes whose products provide the cell with ammonia or glutamate. NAC represses genes whose products use ammonia and also represses its own transcription. In addition, NAC also subtly adjusts other cellular functions to keep pace with the supply of biosynthetically available nitrogen.
摘要
氮同化控制蛋白 (NAC) 是一种 LysR 型转录调节因子 (LTTR)，在氮限制生长条件下合成。NAC 的合成完全依赖于双组分 Ntr 系统中的磷酸化 NtrC，并且 nac 基因的转录需要不寻常的 σ54 因子。NAC 激活依赖于 σ70 的基因的转录，其产物为细胞提供氨或谷氨酸。NAC 抑制利用氨的基因的表达，同时也抑制自身的转录。此外，NAC 还微妙地调整其他细胞功能，以适应生物合成可用氮的供应。
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