Population Health Research Institute, McMaster University, Hamilton General Hospital Campus, DB-CVSRI, 237 Barton Street East, Rm. C3102 Hamilton, Ontario, Canada L8L 2X2.
Eur Heart J. 2010 Sep;31(17):2092-6. doi: 10.1093/eurheartj/ehq242. Epub 2010 Jul 30.
A large number of studies have evaluated the association of hs-C-reactive protein with atherosclerosis and coronary heart disease (CHD) in mechanistic, genetic, population-based studies, as well as clinical trials. This paper reviews the collective evidence to determine if hs-C-reactive protein is part of the causal pathway of atherosclerosis and CHD or whether it is a bystander.
大量研究通过机制研究、遗传研究、基于人群的研究以及临床试验评估了高敏 C 反应蛋白与动脉粥样硬化和冠心病(CHD)的相关性。本文综述了现有证据,以确定高敏 C 反应蛋白是否是动脉粥样硬化和 CHD 的因果途径的一部分,还是一个旁观者。