Department of Vascular Medicine, Academic Medical Center, PO Box 22660, 1100 DD Amsterdam, The Netherlands.
Eur Heart J. 2010 Sep;31(17):2087-91. doi: 10.1093/eurheartj/ehq238. Epub 2010 Aug 3.
C-reactive protein is postulated to embody an index that can reflect cardiovascular risk and can be used to independently predict major cardiovascular events and mortality. On the other hand, credible experimental data have become available that demonstrate the abundant presence of C-reactive protein in atherosclerotic lesions and, moreover, identify C-reactive protein as an initiator of several pathogenic pathways that can cause atherogenic changes. Consequently, there has been a paradigm shift in which C-reactive protein is no longer regarded as merely an indicator of cardiovascular risk, but increasingly considered a direct partaker in the pathogenesis of atherosclerotic cardiovascular disease. These data underscore the need to explore risk-reducing interventions that selectively inhibit C-reactive protein activity as a novel strategy to prevent clinical manifestations of atherosclerosis.
C 反应蛋白被认为是一种可以反映心血管风险的指标，可用于独立预测主要心血管事件和死亡率。另一方面，有大量可信的实验数据表明 C 反应蛋白在动脉粥样硬化病变中大量存在，并且将 C 反应蛋白确定为可以引起动脉粥样变化的几个致病途径的启动子。因此，已经发生了范式转变，其中 C 反应蛋白不再仅仅被视为心血管风险的指标，而是越来越被认为是动脉粥样硬化性心血管疾病发病机制的直接参与者。这些数据强调了需要探索选择性抑制 C 反应蛋白活性的降低风险干预措施，作为预防动脉粥样硬化临床表现的新策略。
